# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5046505 | Functional | Anti-neuroinflammation in mouse BV-2 cells assessed as inhibition of LPS-induced NO production at 1 uM preincubated for 6 hrs followed by LPS addition measured after 24 hrs by Griess reagent based assay | Mus musculus | 21 | ALA5046219 | cell-based format | Scientific Literature | |
2. | ALA5046506 | Binding | Inhibition of human iNOS assessed as reduction in L-[3H]-citrulline level using L-[3H]-arginine as substrate incubated for 1 hr | Homo sapiens | 22 | ALA5046219 | single protein format | Scientific Literature | |
3. | ALA5046507 | Binding | Inhibition of human nNOS assessed as reduction in L-[3H]-citrulline level using L-[3H]-arginine as substrate incubated for 1 hr | Homo sapiens | 22 | ALA5046219 | single protein format | Scientific Literature | |
4. | ALA5046508 | Binding | Inhibition of human eNOS assessed as reduction in L-[3H]-citrulline level using L-[3H]-arginine as substrate incubated for 1 hr | Homo sapiens | 22 | ALA5046219 | single protein format | Scientific Literature | |
5. | ALA5046509 | Binding | Selectivity ratio of IC50 for human nNOS to IC50 for human iNOS | Homo sapiens | 22 | ALA5046219 | protein format | Scientific Literature | |
6. | ALA5046510 | Binding | Selectivity ratio of IC50 for human eNOS to IC50 for human iNOS | Homo sapiens | 22 | ALA5046219 | assay format | Scientific Literature | |
7. | ALA5046511 | ADME | Effective permeability of compound in PBS buffer at pH 7.4 at 200 uM incubated for 17 hrs by PAMPA-BBB assay | 10 | ALA5046219 | assay format | Scientific Literature | ||
8. | ALA5046533 | ADME | AUC (0 to infinity) in Balb/c mouse brain at 30 mg/kg, po administered as single dose measured upto 24 hrs by LC-MS analysis | Mus musculus | 2 | ALA5046219 | organism-based format | Scientific Literature | |
9. | ALA5046534 | ADME | AUC (0 to infinity) in Balb/c mouse blood at 30 mg/kg, po administered as single dose measured upto 24 hrs by LC-MS analysis | Mus musculus | 2 | ALA5046219 | organism-based format | Scientific Literature | |
10. | ALA5046544 | ADME | Half life in Balb/c mouse blood at 30 mg/kg, po administered as single dose measured upto 24 hrs by LC-MS analysis | Mus musculus | 2 | ALA5046219 | organism-based format | Scientific Literature | |
11. | ALA5046545 | ADME | Half life in Balb/c mouse brain at 30 mg/kg, po administered as single dose measured upto 24 hrs by LC-MS analysis | Mus musculus | 2 | ALA5046219 | organism-based format | Scientific Literature | |
12. | ALA5046546 | ADME | Cmax in Balb/c mouse blood at 30 mg/kg, po administered as single dose measured upto 24 hrs by LC-MS analysis | Mus musculus | 2 | ALA5046219 | organism-based format | Scientific Literature | |
13. | ALA5046547 | ADME | Cmax in Balb/c mouse brain at 30 mg/kg, po administered as single dose measured upto 24 hrs by LC-MS analysis | Mus musculus | 2 | ALA5046219 | organism-based format | Scientific Literature |