| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5056107 | B | Inhibition of GST-tagged dog GRP94 (69 to 337 residues) expressed in Escherichia coli BL21 (DE3) at 100 uM measured after 4 hrs by fluorescent polarization assay relative to control | Canis lupus familiaris | 36 | assay format | Scientific Literature | ||
| 2. | ALA5056108 | B | Inhibition of GST-tagged dog GRP94 (69 to 337 residues) expressed in Escherichia coli BL21 (DE3) measured after 4 hrs by fluorescent polarization assay | Canis lupus familiaris | 36 | assay format | Scientific Literature | ||
| 3. | ALA5056109 | B | Binding affinity to GST-tagged dog GRP94 (69 to 337 residues) expressed in Escherichia coli BL21 (DE3) at 0.37 to 10 uM measured by BLI assay | Canis lupus familiaris | 1 | assay format | Scientific Literature | ||
| 4. | ALA5056110 | B | Binding affinity to GST-tagged dog GRP94 (69 to 337 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant at 0.37 to 10 uM measured by BLI assay | Canis lupus familiaris | 1 | assay format | Scientific Literature | ||
| 5. | ALA5056111 | B | Binding affinity to GST-tagged dog GRP94 (69 to 337 residues) expressed in Escherichia coli BL21 (DE3) assessed as association constant at 0.37 to 10 uM measured by BLI assay | Canis lupus familiaris | 1 | assay format | Scientific Literature | ||
| 6. | ALA5056112 | B | Binding affinity to His-tagged human N-terminal HSP90alpha (1 to 236 residues) expressed in Escherichia coli BL21 (DE3) at 1.1 to 30 uM measured by BLI assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 7. | ALA5056113 | B | Binding affinity to His-tagged human N-terminal HSP90alpha (1 to 236 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant at 1.1 to 30 uM measured by BLI assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 8. | ALA5056114 | B | Binding affinity to His-tagged human N-terminal HSP90alpha (1 to 236 residues) expressed in Escherichia coli BL21 (DE3) assessed as association constant at 1.1 to 30 uM measured by BLI assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 9. | ALA5056115 | B | Inhibition of human HSP90 alpha in human HCT-116 cells assessed as expression of HSP70 measured by Western blot assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA5056116 | B | Inhibition of human HSP90 alpha in human HCT-116 cells assessed as expression of AKT measured by Western blot assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA5056119 | P | Lipophilicity, logD of compound at pH 7.4 | 3 | small-molecule physicochemical format | Scientific Literature | |||
| 12. | ALA5056120 | P | Aqueous solubility of compound | 3 | small-molecule physicochemical format | Scientific Literature | |||
| 13. | ALA5056121 | A | Permeability of compound at pH 7.4 | 3 | assay format | Scientific Literature | |||
| 14. | ALA5056122 | A | Tmax in Sprague-Dawley rat at 10 mg/kg, iv measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA5056123 | A | Tmax in Sprague-Dawley rat at 40 mg/kg, po measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA5056124 | A | Half life in Sprague-Dawley rat at 10 mg/kg, iv measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA5056125 | A | Half life in Sprague-Dawley rat at 40 mg/kg, po measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA5056126 | A | Cmax in Sprague-Dawley rat at 10 mg/kg, iv measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA5056127 | A | Cmax in Sprague-Dawley rat at 40 mg/kg, po measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA5056128 | A | AUC (0 to infinity) in Sprague-Dawley rat at 10 mg/kg, iv measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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