| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5048789 | A | Metabolic stability in human liver microsomes assessed compound remaining measured after 10 mins in presence of NADPH | Homo sapiens | 25 | microsome format | Scientific Literature | ||
| 2. | ALA5048790 | A | Cmax in mouse at 30 mg/kg, po measured after 8 hrs by LC-MS/MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 3. | ALA5048791 | B | Antagonist activity at human CXCR4 receptor expressed in CCRF-CEM cells assessed as inhibition of CXCL12-induced calcium release by calcium flux assay | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
| 4. | ALA5048792 | A | Metabolic stability in mouse liver microsomes assessed compound remaining measured after 10 mins in presence of NADPH | Mus musculus | 25 | microsome format | Scientific Literature | ||
| 5. | ALA5048793 | B | Antagonist activity at mAChR (unknown origin) expressed in CCRF-CEM cells assessed as inhibition of calcium release by calcium flux assay | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
| 6. | ALA5048794 | A | Permeability of compound at pH 7.4 incubated for 4 hrs by PAMPA assay | 25 | assay format | Scientific Literature | |||
| 7. | ALA5048795 | A | Permeability of compound at pH 5.5 incubated for 4 hrs by PAMPA assay | 25 | assay format | Scientific Literature | |||
| 8. | ALA5048796 | A | Inhibition of recombinant human CYP2D6 using AMMC as substrate preincubated for 30 mins followed by substrate addition measured after 45 mins by fluorescence based assay | Homo sapiens | 25 | single protein format | Scientific Literature | ||
| 9. | ALA5048797 | A | Metabolic stability in rat liver microsomes assessed compound remaining measured after 10 mins in presence of NADPH | Rattus norvegicus | 25 | microsome format | Scientific Literature | ||
| 10. | ALA5048798 | T | Cytotoxicity against human TZM-bl cells assessed as reduction in cell viability incubated for 4 hrs by calorimetric assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 11. | ALA5048799 | F | Antiviral activity against HIV-1 Z1800M E4.02 (R5) pseudovirus infected in human TZM-blcells assessed as reduction in viral infectivity measured after 48 hrs of postinfection by luminescence assay | Human immunodeficiency virus 1 | 4 | organism-based format | Scientific Literature | ||
| 12. | ALA5048800 | F | Antiviral activity against HIV-1 NL4-3(X4) pseudovirus infected in human TZM-bl cells assessed as reduction in viral infectivity measured after 48 hrs of postinfection by luminescence assay | Human immunodeficiency virus 1 | 4 | organism-based format | Scientific Literature | ||
| 13. | ALA5048801 | B | Inhibition of alpha 2A adrenergic receptor (unknown origin) | Homo sapiens | 10 | single protein format | Scientific Literature | ||
| 14. | ALA5048802 | B | Inhibition of alpha 2C adrenergic receptor (unknown origin) | Homo sapiens | 10 | single protein format | Scientific Literature | ||
| 15. | ALA5048803 | B | Inhibition of mu opioid receptor (unknown origin) | Homo sapiens | 10 | single protein format | Scientific Literature | ||
| 16. | ALA5048804 | B | Inhibition of kappa opioid receptor (unknown origin) | Homo sapiens | 10 | single protein format | Scientific Literature | ||
| 17. | ALA5048805 | B | Inhibition of dopamine D2 receptor (unknown origin) | Homo sapiens | 10 | single protein format | Scientific Literature | ||
| 18. | ALA5048806 | B | Inhibition of M2 mAChR receptor (unknown origin) | Homo sapiens | 10 | single protein format | Scientific Literature | ||
| 19. | ALA5048807 | B | Inhibition of alpha7 nicotinic acetylcholine receptor (unknown origin) | Homo sapiens | 10 | single protein format | Scientific Literature | ||
| 20. | ALA5048808 | T | Inhibition of human ERG by [3H]]Astemizole binding assay | Homo sapiens | 10 | assay format | Scientific Literature |
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