# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5042312 | Binding | Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay | Homo sapiens | 14 | ALA5038671 | single protein format | Scientific Literature | |
2. | ALA5042313 | Binding | Protac activity at PDE delta in human SW480 cells assessed as PDE delta degradation at 10 uM for 24 hrs by western blot analysis | Homo sapiens | 5 | ALA5038671 | cell-based format | Scientific Literature | |
3. | ALA5042314 | Binding | Protac activity at PDE delta in human SW480 cells assessed as PDE delta degradation at 1 uM for 24 hrs by western blot analysis | Homo sapiens | 4 | ALA5038671 | cell-based format | Scientific Literature | |
4. | ALA5042315 | Binding | Protac activity at PDE delta in human SW480 cells assessed as PDE delta degradation incubated for 24 hrs by western blot analysis | Homo sapiens | 1 | ALA5038671 | cell-based format | Scientific Literature | |
5. | ALA5042316 | Functional | Down regulation of p-Akt expression in human SW480 cells measured for 24 hrs by western blot analysis | Homo sapiens | 1 | ALA5038671 | cell-based format | Scientific Literature | |
6. | ALA5042317 | Functional | Down regulation of p-ERK expression in human SW480 cells measured for 24 hrs by western blot analysis | Homo sapiens | 1 | ALA5038671 | cell-based format | Scientific Literature | |
7. | ALA5042318 | Functional | Down regulation of t-Akt expression in human SW480 cells measured for 24 hrs by western blot analysis | Homo sapiens | 1 | ALA5038671 | cell-based format | Scientific Literature | |
8. | ALA5042319 | Functional | Down regulation of t-ERK expression in human SW480 cells measured for 24 hrs by western blot analysis | Homo sapiens | 1 | ALA5038671 | cell-based format | Scientific Literature | |
9. | ALA5042320 | Functional | Antiproliferative activity against human SW480 cells assessed as cell growth inhibition and measured after 72 hrs by CCK8 assay | Homo sapiens | 14 | ALA5038671 | cell-based format | Scientific Literature | |
10. | ALA5042321 | Functional | Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition and measured after 72 hrs by CCK8 assay | Homo sapiens | 14 | ALA5038671 | cell-based format | Scientific Literature | |
11. | ALA5042323 | Functional | Antiproliferative activity against human SW480 cells assessed as apoptosis induction at 30 uM measured for 24 hrs by Annexin V-FITC/PI staining based flow cytometry analysis (Rvb = 46%) | Homo sapiens | 1 | ALA5038671 | cell-based format | Scientific Literature | |
12. | ALA5042324 | Functional | Antiproliferative activity against human SW480 cells assessed as apoptosis induction at 40 uM measured for 24 hrs by Annexin V-FITC/PI staining based flow cytometry analysis (Rvb = 46%) | Homo sapiens | 1 | ALA5038671 | cell-based format | Scientific Literature |