# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5040190 | F | Suppression of MEIS1 gene expression in human MV4-11 cells at 30 nM measured after 24 hrs by qRT-PCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
2. | ALA5040191 | B | Binding affinity to menin (unknown origin) incubated for 1 hr by fluorescence polarization-based competitive binding assay | Homo sapiens | 20 | single protein format | Scientific Literature | ||
3. | ALA5040192 | F | Anti-proliferative activity against human MV4-11 cells harboring MLL/AF4 fusion protein assessed as cell growth inhibition measured after 4 days by Cell Titre Glo Luminescent Cell viability assay | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
4. | ALA5040193 | F | Anti-proliferative activity against human MOLM-13 cells harboring MLL/AF9 fusion protein assessed as cell growth inhibition measured after 4 days by Cell Titre Glo Luminescent Cell viability assay | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
5. | ALA5040194 | B | Binding affinity to recombinant human menin protein assessed as covalent complex formation incubated for 10 mins by LC/MS analysis | Homo sapiens | 8 | single protein format | Scientific Literature | ||
6. | ALA5040195 | B | Binding affinity to recombinant human menin protein assessed as covalent complex formation incubated for 30 mins by LC/MS analysis | Homo sapiens | 8 | single protein format | Scientific Literature | ||
7. | ALA5040196 | B | Binding affinity to recombinant human menin protein assessed as covalent complex formation incubated for 1 hrs by LC/MS analysis | Homo sapiens | 8 | single protein format | Scientific Literature | ||
8. | ALA5040197 | B | Binding affinity to recombinant human menin protein assessed as covalent complex formation measured after overnight incubation by LC/MS analysis | Homo sapiens | 8 | single protein format | Scientific Literature | ||
9. | ALA5040198 | A | Clearance in C57BL/6 mouse at 1 mg/kg, iv | Mus musculus | 1 | organism-based format | Scientific Literature | ||
10. | ALA5040199 | A | Volume of distribution at steady state in C57BL/6 mouse at 1 mg/kg, iv | Mus musculus | 1 | organism-based format | Scientific Literature | ||
11. | ALA5040200 | A | AUC (0 to infinity) in C57BL/6 mouse at 1 mg/kg, iv | Mus musculus | 1 | organism-based format | Scientific Literature | ||
12. | ALA5040201 | A | Tmax in C57BL/6 mouse at 5 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
13. | ALA5040202 | A | Cmax in C57BL/6 mouse at 5 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
14. | ALA5040203 | A | AUC (0 to infinity) in C57BL/6 mouse at 5 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
15. | ALA5040204 | A | Oral bioavailability in C57BL/6 mouse at 5 mg/kg | Mus musculus | 1 | organism-based format | Scientific Literature | ||
16. | ALA5040205 | A | Plasma concentration in mouse at 25 mg/kg, po measured after 1 hr | Mus musculus | 3 | organism-based format | Scientific Literature | ||
17. | ALA5040206 | A | Plasma concentration in mouse at 25 mg/kg, po measured after 3 hrs | Mus musculus | 3 | organism-based format | Scientific Literature | ||
18. | ALA5040207 | A | Plasma concentration in mouse at 25 mg/kg, po measured after 6 hrs | Mus musculus | 3 | organism-based format | Scientific Literature | ||
19. | ALA5040208 | F | Anti-proliferative activity against human OCI-AML-4 cells harboring MLL-ENL fusion protein assessed as cell growth inhibition measured after 4 days by Cell Titre Glo Luminescent Cell viability assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
20. | ALA5040209 | F | Anti-proliferative activity against human SEM cells harboring MLL/AF4 fusion protein assessed as cell growth inhibition measured after 4 days by Cell Titre Glo Luminescent Cell viability assay | Homo sapiens | 1 | cell-based format | Scientific Literature |