# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5050871 | B | Inhibition of ATF6 activity in human U2OS cells in presence of ER stress inducer thapsigargin (Tg) measured by TRE-luciferase reporter assay | Homo sapiens | 126 | ALA5050827 | cell-based format | Patent Bioactivity Data | |
2. | ALA5050872 | B | Inhibition of ATF6 activity in human U2OS cells at 1 uM in presence of ER stress inducer thapsigargin (Tg) measured by TRE-luciferase reporter assay relative to control | Homo sapiens | 126 | ALA5050827 | cell-based format | Patent Bioactivity Data | |
3. | ALA5050882 | A | Metabolic stability in human liver microsomes at 1 uM assessed as parent compound remaining after 15 mins in presence of NADPH by LC-MS analysis | Homo sapiens | 25 | ALA5050827 | microsome format | Patent Bioactivity Data | |
4. | ALA5050883 | A | Metabolic stability in mouse liver microsomes at 1 uM assessed as parent compound remaining after 15 mins in presence of NADPH by LC-MS analysis | Mus musculus | 25 | ALA5050827 | microsome format | Patent Bioactivity Data | |
5. | ALA5050884 | A | Metabolic stability in rat liver microsomes at 1 uM assessed as parent compound remaining after 15 mins in presence of NADPH by LC-MS analysis | Rattus norvegicus | 25 | ALA5050827 | microsome format | Patent Bioactivity Data | |
6. | ALA5050885 | A | Half-life in human liver microsomes at 1 uM after 15 mins in presence of NADPH by LC-MS analysis | Homo sapiens | 25 | ALA5050827 | microsome format | Patent Bioactivity Data | |
7. | ALA5050886 | A | Half-life in mouse liver microsomes at 1 uM after 15 mins in presence of NADPH by LC-MS analysis | Mus musculus | 25 | ALA5050827 | microsome format | Patent Bioactivity Data | |
8. | ALA5050887 | A | Half-life in rat liver microsomes at 1 uM after 15 mins in presence of NADPH by LC-MS analysis | Rattus norvegicus | 25 | ALA5050827 | microsome format | Patent Bioactivity Data | |
9. | ALA5050888 | A | Intrinsic clearance in human liver microsomes at 1 uM after 15 mins in presence of NADPH by LC-MS analysis | Homo sapiens | 25 | ALA5050827 | microsome format | Patent Bioactivity Data | |
10. | ALA5050889 | A | Intrinsic clearance in mouse liver microsomes at 1 uM after 15 mins in presence of NADPH by LC-MS analysis | Mus musculus | 25 | ALA5050827 | microsome format | Patent Bioactivity Data | |
11. | ALA5050890 | A | Intrinsic clearance in rat liver microsomes at 1 uM after 15 mins in presence of NADPH by LC-MS analysis | Rattus norvegicus | 25 | ALA5050827 | microsome format | Patent Bioactivity Data | |
12. | ALA5050891 | P | Kinetic solubility of compound in in PBS buffer at pH 7.4 | 25 | ALA5050827 | small-molecule physicochemical format | Patent Bioactivity Data | ||
13. | ALA5050892 | A | Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate incubated for 20 mins in presence of NADPH and measured by LC-MS/MS analysis | Homo sapiens | 17 | ALA5050827 | microsome format | Patent Bioactivity Data | |
14. | ALA5050893 | A | Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate incubated for 20 mins in presence of NADPH and measured by LC-MS/MS analysis | Homo sapiens | 17 | ALA5050827 | microsome format | Patent Bioactivity Data | |
15. | ALA5050894 | A | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate incubated for 20 mins in presence of NADPH and measured by LC-MS/MS analysis | Homo sapiens | 17 | ALA5050827 | microsome format | Patent Bioactivity Data | |
16. | ALA5050895 | A | Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate incubated for 20 mins in presence of NADPH and measured by LC-MS/MS analysis | Homo sapiens | 17 | ALA5050827 | microsome format | Patent Bioactivity Data | |
17. | ALA5050896 | A | Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate incubated for 20 mins in presence of NADPH and measured by LC-MS/MS analysis | Homo sapiens | 17 | ALA5050827 | microsome format | Patent Bioactivity Data | |
18. | ALA5050897 | A | Inhibition of CYP2C19 in human liver microsomes using mephenytoin as substrate incubated for 40 mins in presence of NADPH and measured by LC-MS/MS analysis | Homo sapiens | 17 | ALA5050827 | microsome format | Patent Bioactivity Data | |
19. | ALA5050898 | A | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 10 mins in presence of NADPH and measured by LC-MS/MS analysis | Homo sapiens | 17 | ALA5050827 | microsome format | Patent Bioactivity Data |