Antitumor activity against mouse MC38 cells xenografted in C57BL/6 mouse assessed as inhibition of tumor growth at 30 mg/kg, po twice daily co-administered with anti-PD1-antibody at 5 mg/kg, ip twice weekly for 2 weeks
Antitumor activity against mouse MC38 cells xenografted in C57BL/6 mouse assessed as increase in animal survival at 30 mg/kg, po twice daily co-administered with anti-PD1-antibody at 5 mg/kg, ip twice weekly for 2 weeks
Antitumor activity against mouse 4T1 cells xenografted in Balb/cj mouse assessed as inhibition of tumor growth at 30 mg/kg, po twice daily for 21 days relative to control
Antitumor activity against mouse 4T1 cells xenografted in Balb/cj mouse assessed as inhibition of tumor growth at 30 mg/kg, po twice daily for 21 days in presence of 4-1BB monoclonal antibody relative to control
Antitumor activity against mouse 4T1 cells xenografted in Balb/cj mouse assessed as inhibition of tumor growth at 30 mg/kg, po twice daily for 21 days in presence of OXO40 monoclonal antibody relative to control
Antitumor activity against mouse CT26 cells xenografted in Balb/c mouse assessed as time of events at 30 mg/kg, po twice daily for 28 days in presence of ant-CTLA4 antibody
Antitumor activity against mouse CT26 cells xenografted in Balb/c mouse assessed as tumor growth delay at 30 mg/kg, po twice daily for 28 days in presence of ant-CTLA4 antibody