| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5125545 | Binding | Inhibition of SETD2 (1434 to 1711 residues) (unknown origin) using SAM and biotin-Ahx-RKSAPATGGVKKPHR-NH2 as substrate preincubated for 30 mins followed by substrate addition by topcount scintillation counting method | Homo sapiens | 10 | ALA5120931 | single protein format | Scientific Literature | |
| 2. | ALA5125546 | Binding | Inhibition of SETD2 in human A549 cells assessed as reduction in H3K36me3 incubated for 3 days by in-cell western assay | Homo sapiens | 10 | ALA5120931 | cell-based format | Scientific Literature | |
| 3. | ALA5125547 | Functional | Antiproliferative activity against human KMS-34 cells assessed as reduction in cell viability incubated for 14 days by CellTiter-glo luminescence assay | Homo sapiens | 10 | ALA5120931 | cell-based format | Scientific Literature | |
| 4. | ALA5125548 | ADME | Apparent permeability across apical to basal side in human Caco-2 cells at 5 uM measured after 2 hrs by LC-MS/MS analysis | Homo sapiens | 6 | ALA5120931 | cell-based format | Scientific Literature | |
| 5. | ALA5125549 | ADME | Apparent permeability across basal to apical side in human Caco-2 cells at 5 uM measured after 2 hrs by LC-MS/MS analysis | Homo sapiens | 6 | ALA5120931 | cell-based format | Scientific Literature | |
| 6. | ALA5125550 | ADME | Stability in human hepatocytes assessed as intrinsic clearance at 0.5 uM measured after 120 mins by LC/MS/MS analysis | Homo sapiens | 6 | ALA5120931 | cell-based format | Scientific Literature | |
| 7. | ALA5125551 | ADME | Stability in rat hepatocytes assessed as intrinsic clearance at 0.5 uM measured after 60 mins by LC/MS/MS analysis | Rattus norvegicus | 6 | ALA5120931 | cell-based format | Scientific Literature | |
| 8. | ALA5125552 | ADME | Stability in mouse hepatocytes assessed as intrinsic clearance at 0.5 uM measured after 60 mins by LC/MS/MS analysis | Mus musculus | 6 | ALA5120931 | cell-based format | Scientific Literature | |
| 9. | ALA5125553 | ADME | Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate preincubated for 5 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysis | Homo sapiens | 2 | ALA5120931 | microsome format | Scientific Literature | |
| 10. | ALA5125554 | ADME | Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 5 mins followed by NADPH addition measured after 20 mins by LC-MS/MS analysis | Homo sapiens | 2 | ALA5120931 | microsome format | Scientific Literature | |
| 11. | ALA5125555 | ADME | Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by NADPH addition measured after 20 mins by LC-MS/MS analysis | Homo sapiens | 2 | ALA5120931 | microsome format | Scientific Literature | |
| 12. | ALA5125556 | ADME | Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate preincubated for 5 mins followed by NADPH addition measured after 20 mins by LC-MS/MS analysis | Homo sapiens | 2 | ALA5120931 | microsome format | Scientific Literature | |
| 13. | ALA5125557 | ADME | Inhibition of CYP2C19 in human liver microsomes using (s)-mephenytoin as substrate preincubated for 5 mins followed by NADPH addition measured after 20 mins by LC-MS/MS analysis | Homo sapiens | 2 | ALA5120931 | microsome format | Scientific Literature | |
| 14. | ALA5125558 | ADME | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 5 mins followed by NADPH addition measured after 20 mins by LC-MS/MS analysis | Homo sapiens | 2 | ALA5120931 | microsome format | Scientific Literature | |
| 15. | ALA5125559 | ADME | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 5 mins followed by NADPH addition measured after 5 mins by LC-MS/MS analysis | Homo sapiens | 2 | ALA5120931 | microsome format | Scientific Literature | |
| 16. | ALA5125560 | Functional | Antiproliferative activity against human KMS-11 cells assessed as reduction in cell viability incubated for 14 days by CellTiter-glo luminescence assay | Homo sapiens | 1 | ALA5120931 | cell-based format | Scientific Literature | |
| 17. | ALA5125561 | Functional | Antagonist activity at D2 receptor (unknown origin) | Homo sapiens | 1 | ALA5120931 | assay format | Scientific Literature | |
| 18. | ALA5125562 | Functional | Agonist activity at 5-HT1B receptor (unknown origin) | Homo sapiens | 1 | ALA5120931 | assay format | Scientific Literature | |
| 19. | ALA5125563 | Functional | Antitumor activity against human KMS-11 cells xenografted in NOD SCID mouse assessed as reduction in tumor growth at 15 mg/kg, po bid administered starting from day 7 to 37 days post-inoculation | Homo sapiens | 1 | ALA5120931 | organism-based format | Scientific Literature | |
| 20. | ALA5125564 | Functional | Antitumor activity against human KMS-11 cells xenografted in NOD SCID mouse assessed as reduction in tumor growth at 30 mg/kg, po bid administered starting from day 7 to 37 days post-inoculation | Homo sapiens | 1 | ALA5120931 | organism-based format | Scientific Literature |
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