| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5162472 | A | Stability in Sprague-Dawley rat hepatocytes assessed as clearance per 10^-6 cells at 1 uM after 20 mins by LC-MS/MS analysis | Rattus norvegicus | 5 | cell-based format | Scientific Literature | ||
| 2. | ALA5162473 | P | Solubility of compound in PBS at 10 mM after 3 hrs by UV analysis | 5 | small-molecule physicochemical format | Scientific Literature | |||
| 3. | ALA5162476 | B | Agonist activity at NPRC in rat small mesenteric arteries assessed as vasorelaxation by Organ bath assay | Rattus norvegicus | 5 | tissue-based format | Scientific Literature | ||
| 4. | ALA5162477 | B | Agonist activity at NPRC in rat aorta assessed as vasorelaxation by Organ bath assay | Rattus norvegicus | 8 | tissue-based format | Scientific Literature | ||
| 5. | ALA5162480 | A | Permeability of the compound in PBS at pH 7.4 incubated for 5 hrs by LC/MS based PAMPA assay | 5 | assay format | Scientific Literature | |||
| 6. | ALA5162481 | A | Stability in Sprague-Dawley rat hepatocytes assessed as half life at 1 uM after 20 mins by LC-MS/MS analysis | Rattus norvegicus | 5 | cell-based format | Scientific Literature | ||
| 7. | ALA5162482 | A | Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 10 mins followed by NADPH addition and measured after 10 mins by LC/MS/MS analysis | Homo sapiens | 5 | microsome format | Scientific Literature | ||
| 8. | ALA5162483 | A | Stability of compound in pooled human plasma assessed as half life measured upto 120 mins by LC/MS/MS analysis | Homo sapiens | 5 | cell-free format | Scientific Literature | ||
| 9. | ALA5162484 | A | Protein binding in human plasma by equilibrium dialysis assay | Homo sapiens | 5 | cell-free format | Scientific Literature | ||
| 10. | ALA5162485 | A | Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate preincubated for 10 mins followed by NADPH addition and measured after 20 mins by LC/MS/MS analysis | Homo sapiens | 5 | microsome format | Scientific Literature | ||
| 11. | ALA5162486 | A | Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 10 mins followed by NADPH addition and measured after 10 mins by LC/MS/MS analysis | Homo sapiens | 3 | microsome format | Scientific Literature | ||
| 12. | ALA5162487 | A | Inhibition of CYP2C8 in human liver microsomes using amodiaquine as a substrate preincubated for 10 mins followed by NADPH addition and measured after 10 mins by LC/MS/MS analysis | Homo sapiens | 4 | microsome format | Scientific Literature | ||
| 13. | ALA5162488 | A | Inhibition of CYP3A4 in human liver microsomes using midazolam as a substrate preincubated for 10 mins followed by NADPH addition and measured after 20 mins by LC/MS/MS analysis | Homo sapiens | 4 | microsome format | Scientific Literature | ||
| 14. | ALA5162489 | A | Inhibition of CYP3A4 in human liver microsomes using testosterone as a substrate preincubated for 10 mins followed by NADPH addition and measured after 10 mins by LC/MS/MS analysis | Homo sapiens | 4 | microsome format | Scientific Literature | ||
| 15. | ALA5162507 | B | Agonist activity at NPRA in human HeLa cells assessed as increased cGMP formation at 10 uM incubated for 30 mins in presence of IBMX by ELISA | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 16. | ALA5162508 | B | Agonist activity at NPRB in human HeLa cells assessed as increased cGMP formation at 10 uM incubated for 30 mins in presence of IBMX by ELISA | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 17. | ALA5162509 | B | Binding affinity to CM5 sensor chip immobilized human NPR-C (27 to 541 residues) assessed as dissociation constant by surface plasmon resonance analysis | Homo sapiens | 22 | single protein format | Scientific Literature |
The page will load shortly, Thanks for your patience!