| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5149027 | B | Inhibition of YAP/TAZ-TEAD interaction in human SK-HEP1 cells incubated for 24 hrs by luciferase reporter gene assay | Homo sapiens | 47 | cell-based format | Scientific Literature | ||
| 2. | ALA5149028 | B | Binding affinity to human TEAD1 (209 to 426 residues) expressed in Escherichia coli BL21 Star (DE3) by surface plasmon resonance assay | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 3. | ALA5149029 | B | Binding affinity to human TEAD2 (217 to 447 residues) expressed in Escherichia coli BL21 Star (DE3) by surface plasmon resonance assay | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 4. | ALA5149030 | B | Binding affinity to human TEAD3 (216 to 435 residues) expressed in Escherichia coli BL21 Star (DE3) by surface plasmon resonance assay | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 5. | ALA5149031 | B | Binding affinity to human TEAD4 (217 to 434 residues) expressed in Escherichia coli BL21 Star (DE3) by surface plasmon resonance assay | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 6. | ALA5149034 | A | Microsomal stability in human microsomes measured per 10^6 cells | Homo sapiens | 7 | microsome format | Scientific Literature | ||
| 7. | ALA5149036 | A | Microsomal stability in human hepatocyte measured per 10^6 cells | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 8. | ALA5149038 | F | Cytotoxicity against human NCI-H226 cells assessed as cell viability at 10 uM measured for 7 days by celltiter-glo assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 9. | ALA5149039 | B | Binding affinity to human TEAD1 (209 to 426 residues) expressed in Escherichia coli BL21 Star (DE3) assessed as change in melting temperature incubated for 2 hrs by measuring tryptophane fluorescence by Nano Differential scanning fluorometry | Homo sapiens | 7 | assay format | Scientific Literature | ||
| 10. | ALA5149040 | B | Binding affinity to human TEAD2 (217 to 447 residues) expressed in Escherichia coli BL21 Star (DE3) assessed as change in melting temperature incubated for 2 hrs by measuring tryptophane fluorescence by Nano Differential scanning fluorometry | Homo sapiens | 7 | assay format | Scientific Literature | ||
| 11. | ALA5149041 | B | Binding affinity to human TEAD3 (216 to 435 residues) expressed in Escherichia coli BL21 Star (DE3) assessed as change in melting temperature incubated for 2 hrs by measuring tryptophane fluorescence by Nano Differential scanning fluorometry | Homo sapiens | 7 | assay format | Scientific Literature | ||
| 12. | ALA5149042 | B | Binding affinity to human TEAD4 (217 to 434 residues) expressed in Escherichia coli BL21 Star (DE3) assessed as change in melting temperature incubated for 2 hr by measuring tryptophane fluorescence by Nano Differential scanning fluorometry | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 13. | ALA5149043 | B | Inhibition of pSF-CMV-P-FLAG tagged human TEAD1 palmitoylation transfected in HEK293 cells at 10 uM incubated for 6 hrs by Western blot analysis relative to control | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 14. | ALA5149044 | B | Inhibition of pSF-CMV-P-FLAG tagged human TEAD2 palmitoylation transfected in HEK293 cells at 10 uM incubated for 6 hrs by Western blot analysis relative to control | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 15. | ALA5149045 | B | Inhibition of pSF-CMV-P-FLAG tagged human TEAD3 palmitoylation transfected in HEK293 cells at 10 uM incubated for 6 hrs by Western blot analysis relative to control | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 16. | ALA5149046 | B | Inhibition of pSF-CMV-P-FLAG tagged human TEAD4 palmitoylation transfected in HEK293 cells at 10 uM incubated for 6 hrs by Western blot analysis relative to control | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 17. | ALA5149047 | B | Inhibition of pSF-CMV-P-FLAG tagged human TEAD1 palmitoylation transfected in HEK293 cells at 100 nM incubated for 6 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA5149048 | B | Inhibition of pSF-CMV-P-FLAG tagged human TEAD3 palmitoylation transfected in HEK293 cells at 1 uM incubated for 6 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA5149049 | B | Binding affinity to human TEAD2 (217 to 447 residues) expressed in Escherichia coli BL21 Star (DE3) assessed as retention time by surface plasmon resonance assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 20. | ALA5149050 | B | Binding affinity to human TEAD1 (209 to 426 residues) expressed in Escherichia coli BL21 Star (DE3) assessed as retention time by surface plasmon resonance assay | Homo sapiens | 1 | assay format | Scientific Literature |
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