# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5142860 | B | Inhibition of PI3Kdelta in human JeKo-1 cells assessed as reduction in AKT autophosphorylation at Thr308 residue | Homo sapiens | 1 | ALA5137107 | cell-based format | Scientific Literature | |
2. | ALA5142861 | B | Inhibition of DNA-PK in human A549 cells assessed as reduction in irradiation-induced autophosphorylation at S2056 residue preincubated for 1 hr followed by 8 Gy irradiation and measured after 1 hr by ELISA | Homo sapiens | 19 | ALA5137107 | cell-based format | Scientific Literature | |
3. | ALA5142862 | B | Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate addition and further incubated for 40 mins in presence of ATP by TR-FRET assay | Homo sapiens | 19 | ALA5137107 | single protein format | Scientific Literature | |
4. | ALA5142863 | P | 1-Octanol/aqueous buffer partition coefficient, logD of the compound at pH 7.4 by shake flask technique based UPLC analysis | 19 | ALA5137107 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA5142864 | T | Inhibition of hERG expressed in CHO cells by electrophysiological assay based automated patch clamp method | Homo sapiens | 14 | ALA5137107 | cell-based format | Scientific Literature | |
6. | ALA5142865 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance measured per mg of protein | Homo sapiens | 17 | ALA5137107 | microsome format | Scientific Literature | |
7. | ALA5142866 | B | Inhibition of PI3Kalpha (unknown origin) at 1 uM relative to control | Homo sapiens | 1 | ALA5137107 | single protein format | Scientific Literature | |
8. | ALA5142869 | A | Plasma protein binding in human assessed as unbound fraction | Homo sapiens | 11 | ALA5137107 | cell-free format | Scientific Literature | |
9. | ALA5142870 | A | Apparent permeability of compound across apical to basal membrane in human Caco-2 by ABBA assay | Homo sapiens | 5 | ALA5137107 | cell-based format | Scientific Literature | |
10. | ALA5142871 | A | Efflux ratio of apparent permeability across basolateral to apical over apical to basolateral membrane in human Caco-2 cells by ABBA assay | Homo sapiens | 5 | ALA5137107 | cell-based format | Scientific Literature | |
11. | ALA5142872 | P | Solubility of the compound in FaSSIF at pH 6.5 | 1 | ALA5137107 | small-molecule physicochemical format | Scientific Literature | ||
12. | ALA5142873 | A | Plasma protein binding in Han Wistar rat assessed as unbound fraction | Rattus norvegicus | 1 | ALA5137107 | cell-free format | Scientific Literature | |
13. | ALA5142874 | A | Plasma protein binding in Beagle dog assessed as unbound fraction | Canis lupus familiaris | 1 | ALA5137107 | cell-free format | Scientific Literature | |
14. | ALA5142875 | A | Metabolic stability in human hepatocytes assessed as intrinsic clearance measured per million cells | Homo sapiens | 1 | ALA5137107 | cell-based format | Scientific Literature | |
15. | ALA5142876 | A | Metabolic stability in Han Wistar rat hepatocytes assessed as intrinsic clearance measured per million cells | Rattus norvegicus | 1 | ALA5137107 | cell-based format | Scientific Literature | |
16. | ALA5142877 | A | Metabolic stability in Beagle dog hepatocytes assessed as intrinsic clearance measured per million cells | Canis lupus familiaris | 1 | ALA5137107 | cell-based format | Scientific Literature | |
17. | ALA5142878 | A | Oral bioavailability in Han Wistar rat at 5 mg/kg | Rattus norvegicus | 1 | ALA5137107 | organism-based format | Scientific Literature | |
18. | ALA5142879 | A | Clearance in Han Wistar rat at 5 mg/kg, po or 2 mg/kg, iv | Rattus norvegicus | 1 | ALA5137107 | organism-based format | Scientific Literature | |
19. | ALA5142880 | A | Volume of distribution at steady state in Han Wistar rat at 5 mg/kg, po or 2 mg/kg, iv | Rattus norvegicus | 1 | ALA5137107 | organism-based format | Scientific Literature | |
20. | ALA5142881 | A | Half life in Han Wistar rat at 5 mg/kg, po or 2 mg/kg, iv | Rattus norvegicus | 1 | ALA5137107 | organism-based format | Scientific Literature |