# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5160794 | Binding | Activation of Nrf2-ARE pathway in human HepG2-ARE-C8 cells assessed as fold upregulation of ARE-inducing luciferase activity at 10 uM measured after 24 hrs by luciferase reporter gene assay | Homo sapiens | 7 | ALA5154780 | cell-based format | Scientific Literature | |
2. | ALA5160795 | Binding | Activation of Nrf2-ARE pathway in human HepG2-ARE-C8 cells assessed as fold upregulation of ARE-inducing luciferase activity at 20 uM measured after 24 hrs by luciferase reporter gene assay | Homo sapiens | 7 | ALA5154780 | cell-based format | Scientific Literature | |
3. | ALA5160796 | Binding | Activation of Nrf2-ARE pathway in human HepG2-ARE-C8 cells assessed as fold upregulation of ARE-inducing luciferase activity at 40 uM measured after 24 hrs by luciferase reporter gene assay | Homo sapiens | 7 | ALA5154780 | cell-based format | Scientific Literature | |
4. | ALA5160797 | Binding | Activation of Nrf2-ARE pathway in human HepG2-ARE-C8 cells assessed as fold upregulation of ARE-inducing luciferase activity at 80 uM measured after 24 hrs by luciferase reporter gene assay | Homo sapiens | 7 | ALA5154780 | cell-based format | Scientific Literature | |
5. | ALA5160798 | Binding | Activation of Nrf2-ARE pathway in human HepG2-ARE-C8 cells assessed as fold upregulation of ARE-inducing luciferase activity at 160 uM measured after 24 hrs by luciferase reporter gene assay | Homo sapiens | 7 | ALA5154780 | cell-based format | Scientific Literature | |
6. | ALA5160803 | Functional | Antiinflammatory activity in PMA-differentiated and LPS-stimulated human THP-1 cell model assessed as inhibition of NLRP3 inflammasome-driven IL-1beta production at 15 uM incubated for 24 hrs followed by LPS stimulation for 3 hrs and ATP addition for 1 hr by ELISA | Homo sapiens | 6 | ALA5154780 | cell-based format | Scientific Literature | |
7. | ALA5160804 | Functional | Antiinflammatory activity in PMA-differentiated and LPS-stimulated human THP-1 cell model assessed as inhibition of NLRP3 inflammasome-driven IL-1beta production at 30 uM incubated for 24 hrs followed by LPS stimulation for 3 hrs and ATP addition for 1 hr by ELISA | Homo sapiens | 6 | ALA5154780 | cell-based format | Scientific Literature | |
8. | ALA5160805 | Functional | Antiinflammatory activity in PMA-differentiated and LPS-stimulated human THP-1 cell model assessed as inhibition of NLRP3 inflammasome-driven IL-1beta production at 45 uM incubated for 24 hrs followed by LPS stimulation for 3 hrs and ATP addition for 1 hr by ELISA | Homo sapiens | 6 | ALA5154780 | cell-based format | Scientific Literature | |
9. | ALA5160806 | Toxicity | Cytotoxicity against human THP-1 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay | Homo sapiens | 6 | ALA5154780 | cell-based format | Scientific Literature | |
10. | ALA5160814 | Binding | Induction of cell membrane permeability in rat PC-12 cells at 60 uM measured after 10 hrs by fluorescence microscopic analysis | Rattus norvegicus | 1 | ALA5154780 | cell-based format | Scientific Literature | |
11. | ALA5160815 | Binding | Binding affinity to recombinant Rpn6 in rat PC-12 cells at 60 uM measured after 12 hrs by DAPI staining based fluorescence microscope assay | Rattus norvegicus | 1 | ALA5154780 | cell-based format | Scientific Literature |