| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5115653 | B | Inhibition of human recombinant OGA at 10 uM pretreated for 20 mins followed by 4-Methylumbelliferyl N-acetyl-(3-D-glucosaminide substrate addition by fluorometer | Homo sapiens | 53 | single protein format | Scientific Literature | ||
| 2. | ALA5115654 | B | Inhibition of human recombinant OGA pretreated for 20 mins followed by 4-Methylumbelliferyl N-acetyl-(3-D-glucosaminide substrate addition by fluorometer | Homo sapiens | 36 | single protein format | Scientific Literature | ||
| 3. | ALA5115655 | B | Inhibition of human recombinant beta-hexosaminidase at 10 uM pretreated with compound followed by 4-nitrophenyl Nacetyl-beta-D-glucosaminide substrate addition by fluorometer | Homo sapiens | 10 | single protein format | Scientific Literature | ||
| 4. | ALA5115656 | T | Cytotoxicity against mouse HT-22 cells assessed as cell viability at 10 uM after 18 hrs by MTT assay | Mus musculus | 10 | cell-based format | Scientific Literature | ||
| 5. | ALA5115657 | A | Permeability of compound by PAMPA | 10 | assay format | Scientific Literature | |||
| 6. | ALA5115658 | A | Tmax in ICR mouse plasma at 20 mg/kg, ip after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA5115659 | A | Cmax in ICR mouse plasma at 20 mg/kg, ip after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA5115660 | A | Half life in ICR mouse plasma at 20 mg/kg, ip after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA5115661 | A | AUCt in ICR mouse plasma at 20 mg/kg, ip after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA5115662 | A | AUCinfinity in ICR mouse plasma at 20 mg/kg, ip after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA5115663 | A | AUClast in ICR mouse plasma at 20 mg/kg, ip after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA5115664 | A | AUClast in ICR mouse brain at 20 mg/kg, ip after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA5115665 | A | Ratio of drug level in ICR mouse brain to plasma at 20 mg/kg, ip after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA5115669 | F | Invivo inhibition of OGA in amyloid-beta-induced ICR mouse assessed as decrease in 4-MUF level at 2 to 20 mg/kg, ip for 3 days by fluorescence analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA5115671 | F | Neuroprotective activity against amyloid beta (1 to 42)-induced cognitive impairement in ICR mouse assessed as spontaneous alteration at 2 mg/kg, ip for 3 days by Y-maze test | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA5115672 | F | Neuroprotective activity against amyloid beta (1 to 42)-induced cognitive impairement in ICR mouse assessed as spontaneous alteration at 20 mg/kg, ip for 3 days by Y-maze test | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA5115674 | F | Anti-alzheimer activity in mouse model assessed as decrease in amyloid beta level in brain at 2 mg/kg, ip for 3 days by ELISA relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA5115675 | F | Anti-alzheimer activity in mouse model assessed as decrease in amyloid beta level in brain at 20 mg/kg, ip for 3 days by ELISA relative to control | Mus musculus | 1 | organism-based format | Scientific Literature |
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