| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5100117 | F | Induction of apoptosis in human SK-BR-3 cells assessed as live cells at 1 uM incubated for 24 hrs by Annexin V-FITC/PI staining based flow cytometry analysis (Rvb= 89.4%) | Homo sapiens | 2 | ALA5096235 | cell-based format | Scientific Literature | |
| 2. | ALA5100118 | B | Binding affinity to recombinant HER2 (unknown origin) assessed as dissociation constant by SPR analysis | Homo sapiens | 10 | ALA5096235 | single protein format | Scientific Literature | |
| 3. | ALA5100119 | B | Binding affinity to HER2 in HER-positive human SK-BR-3 cells assessed as increase in fluorescence intensity at 25 uM by Hoechst 33342 staining based confocal microscopic analysis | Homo sapiens | 4 | ALA5096235 | cell-based format | Scientific Literature | |
| 4. | ALA5100122 | F | Cytotoxicity against HER-positive human SK-BR-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay | Homo sapiens | 7 | ALA5096235 | cell-based format | Scientific Literature | |
| 5. | ALA5100123 | F | Cytotoxicity against HER-positive human NCI-N87 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay | Homo sapiens | 7 | ALA5096235 | cell-based format | Scientific Literature | |
| 6. | ALA5100124 | F | Cytotoxicity against HER-positive human SK-OV-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay | Homo sapiens | 7 | ALA5096235 | cell-based format | Scientific Literature | |
| 7. | ALA5100125 | F | Cytotoxicity against HER-negative human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay | Homo sapiens | 7 | ALA5096235 | cell-based format | Scientific Literature | |
| 8. | ALA5100126 | T | Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay | Homo sapiens | 7 | ALA5096235 | cell-based format | Scientific Literature | |
| 9. | ALA5100131 | F | Induction of apoptosis in human SK-BR-3 cells assessed as early apoptotic cells at 1 uM incubated for 24 hrs by Annexin V-FITC/PI staining based flow cytometry analysis (Rvb= 4.37%) | Homo sapiens | 2 | ALA5096235 | cell-based format | Scientific Literature | |
| 10. | ALA5100132 | F | Induction of apoptosis in human SK-BR-3 cells assessed as late apoptotic cells at 1 uM incubated for 24 hrs by Annexin V-FITC/PI staining based flow cytometry analysis (Rvb= 5.02%) | Homo sapiens | 2 | ALA5096235 | cell-based format | Scientific Literature | |
| 11. | ALA5100133 | F | Induction of apoptosis in human SK-BR-3 cells assessed as dead cells at 1 uM incubated for 24 hrs by Annexin V-FITC/PI staining based flow cytometry analysis (Rvb= 1.21%) | Homo sapiens | 2 | ALA5096235 | cell-based format | Scientific Literature | |
| 12. | ALA5100134 | F | Induction of apoptosis in human SK-BR-3 cells assessed as live cells at 2 uM incubated for 24 hrs by Annexin V-FITC/PI staining based flow cytometry analysis (Rvb= 89.4%) | Homo sapiens | 2 | ALA5096235 | cell-based format | Scientific Literature | |
| 13. | ALA5100135 | F | Induction of apoptosis in human SK-BR-3 cells assessed as early apoptotic cells at 2 uM incubated for 24 hrs by Annexin V-FITC/PI staining based flow cytometry analysis (Rvb= 4.37%) | Homo sapiens | 2 | ALA5096235 | cell-based format | Scientific Literature | |
| 14. | ALA5100136 | F | Induction of apoptosis in human SK-BR-3 cells assessed as late apoptotic cells at 2 uM incubated for 24 hrs by Annexin V-FITC/PI staining based flow cytometry analysis (Rvb= 5.02%) | Homo sapiens | 2 | ALA5096235 | cell-based format | Scientific Literature | |
| 15. | ALA5100137 | F | Induction of apoptosis in human SK-BR-3 cells assessed as dead cells at 2 uM incubated for 24 hrs by Annexin V-FITC/PI staining based flow cytometry analysis (Rvb= 1.21%) | Homo sapiens | 2 | ALA5096235 | cell-based format | Scientific Literature | |
| 16. | ALA5100139 | F | Induction of cell cycle arrest in human SK-BR-3 cells assessed as accumulation of cells at S phase at 1 uM incubated for 24 hrs by flow cytometry analysis (Rvb = 23%) | Homo sapiens | 2 | ALA5096235 | cell-based format | Scientific Literature | |
| 17. | ALA5100140 | F | Induction of cell cycle arrest in human SK-BR-3 cells assessed as accumulation of cells at S phase at 2 uM incubated for 24 hrs by flow cytometry analysis (Rvb = 23%) | Homo sapiens | 2 | ALA5096235 | cell-based format | Scientific Literature | |
| 18. | ALA5100141 | B | Inhibition of topoisomerase 1 (unknown origin) assessed as relaxation of supercoiled plasmid pBR322 DNA at 10 uM preincubated for 20 mins followed by pBR322 DNA addition and measured after 30 mins by agarose gel electrophoresis analysis | Homo sapiens | 2 | ALA5096235 | single protein format | Scientific Literature | |
| 19. | ALA5100142 | B | Inhibition of topoisomerase 1 (unknown origin) assessed as relaxation of supercoiled plasmid pBR322 DNA at 100 uM preincubated for 20 mins followed by pBR322 DNA addition and measured after 30 mins by agarose gel electrophoresis analysis | Homo sapiens | 2 | ALA5096235 | single protein format | Scientific Literature | |
| 20. | ALA5100143 | A | Metabolic stability in Sprague-Dawley rat plasma assessed as drug degradation incubated for 120 mins by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA5096235 | cell-free format | Scientific Literature |
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