| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5161373 | A | Apparent permeability in MDCK-II cells | Canis lupus familiaris | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA5161374 | B | Inhibition of human recombinant IRK assessed as inhibition of phosphorylation activity at 10 uM using 33P-labeleled peptide substrate by radiometric scintillation counting assay relative to control | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 3. | ALA5161375 | B | Inhibition of human recombinant ROCK1 assessed as inhibition of phosphorylation activity at 10 uM 33P-labeleled peptide substrate by radiometric scintillation counting assay relative to control | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 4. | ALA5161376 | B | Inhibition of Ca2+/ CAM stimulated human AC1 activity expressed in AC3 and AC6-knockout HEK293 cells assessed as A23187 stimulated cAMP accumulation incubated for 30 mins followed by A2318 stimulation in presence of IBMX for 1 hr by HTRF assay | Homo sapiens | 36 | cell-based format | Scientific Literature | ||
| 5. | ALA5161377 | B | Inhibition of Ca2+/ CAM stimulated human AC8 activity expressed in AC3 and AC6-knockout HEK293 cells assessed as A23187 stimulated cAMP accumulation incubated for 30 mins followed by A2318 stimulation in presence of IBMX for 1 hr by HTRF assay | Homo sapiens | 36 | cell-based format | Scientific Literature | ||
| 6. | ALA5161378 | B | Inhibition of Ca2+/ CAM stimulated human AC8 activity expressed in AC3 and AC6-knockout HEK293 cells assessed as A23187 stimulated cAMP accumulation incubated for 30 mins followed by A2318 stimulation in presence of IBMX for 1 hr by HTRF assay relative to control | Homo sapiens | 36 | cell-based format | Scientific Literature | ||
| 7. | ALA5161379 | T | Cytotoxicity against HEK293 cells assessed as reduction in cell viability at 30 uM incubated for 1 hr by cell titer glo assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 8. | ALA5161381 | B | Inhibition of Ca2+/ CAM stimulated human AC8 expressed in AC3 and AC6-knockout HEK293 cells assessed as A23187 stimulated cAMP accumulation at 10 uM incubated for 30 mins followed by A2318 stimulation in presence of IBMX for 1 hr by HTRF assay relative to control | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 9. | ALA5161382 | B | Potentiation of PMA-stimulted human AC2 activity in AC3 and AC6-knockout HEK293 cells PMA stimulated cAMP accumulation at 10 uM incubated for 30 mins followed by PMA stimulation in presence of IBMX for 1 hr by HTRF assay relative to control | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 10. | ALA5161383 | B | Inhibition of forskolin stimulated human AC5 activity in C3 and AC6-knockout HEK293 cells assessed as forskolin stimulated cAMP accumulation at 10 uM incubated for 30 mins followed by forskolin stimulation in presence of IBMX for 1 hr by HTRF assay relative to control | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 11. | ALA5161386 | B | Modulation of mu opioid receptor (unknown origin) at 10 uM by radioligand displacement assay | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 12. | ALA5161387 | B | Modulation of kappa opioid receptor (unknown origin) at 10 uM by radioligand displacement assay | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 13. | ALA5161388 | B | Modulation of delta opioid receptor (unknown origin) at 10 uM by radioligand displacement assay | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 14. | ALA5161389 | B | Inhibition of human recombinant VEGFR2 assessed as inhibition of phosphorylation activity at 10 uM using 33P-labeleled peptide substrate by radiometric scintillation counting assay relative to control | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 15. | ALA5161390 | B | Inhibition of human full length recombinant LCK assessed as inhibition of phosphorylation activity at 10 uM using 33P-labeleled peptide substrate by radiometric scintillation counting assay relative to control | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 16. | ALA5161391 | T | Displacement of [3H]astemizole from human ERG expressed in HEK293 cell membrane at 10 uM by Radiometric displacement assay relative to control | Homo sapiens | 2 | cell membrane format | Scientific Literature | ||
| 17. | ALA5161392 | P | Thermodynamic solubility of the compound in PBS at pH 7.4 | 4 | small-molecule physicochemical format | Scientific Literature | |||
| 18. | ALA5161393 | A | Inhibition of CYP1A2 (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 19. | ALA5161394 | A | Inhibition of CYP2C19 (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 20. | ALA5161395 | A | Inhibition of CYP2C9 (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | single protein format | Scientific Literature |
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