AUCinfinity in ICR mouse at 40 mg/kg, ip administered as vehicle 1 as DMSO/Cremophor EL/ PEG400/ DDW formulation measured upto 1440 mins by LC-MS/MS analysis
Antiproliferative activity against human Ca-Ski cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
Metabolic stability in mouse liver microsomes assessed as parent compound remaining at 5 uM preincubated for 5 mins with NADPH followed by compound addition and measured after 15 mins by LC-MS/MS analysis
AUClast in ICR mouse at 40 mg/kg, ip administered as vehicle 1 as DMSO/Cremophor EL/ PEG400/ DDW formulation measured upto 1440 mins by LC-MS/MS analysis
Terminal half life in ICR mouse at 40 mg/kg, ip administered as vehicle 1 as DMSO/Cremophor EL/ PEG400/ DDW formulation measured upto 1440 mins by LC-MS/MS analysis