# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5105455 | B | Agonist activity at human TLR2/TLR6 expressed in HEK-Blue hTLR2-TLR6 cells by SEAP reporter gene based Quanti-blue assay | Homo sapiens | 11 | ALA5104121 | cell-based format | Scientific Literature | |
2. | ALA5105456 | B | Agonist activity at TLR2/TLR6 in human PBMC cells assessed as increase in IL-6 production at 0.1 ug/ml incubated for 24 hrs | Homo sapiens | 7 | ALA5104121 | cell-based format | Scientific Literature | |
3. | ALA5105457 | B | Agonist activity at TLR2/TLR6 in human PBMC cells assessed as increase in IL-10 production at 0.1 ug/ml incubated for 24 hrs | Homo sapiens | 7 | ALA5104121 | cell-based format | Scientific Literature | |
4. | ALA5105458 | B | Agonist activity at TLR2/TLR6 in human PBMC cells assessed as increase in TNF-alpha production at 0.1 ug/ml incubated for 24 hrs | Homo sapiens | 7 | ALA5104121 | cell-based format | Scientific Literature | |
5. | ALA5105459 | B | Agonist activity at TLR2/TLR6 in C57BL/6 mouse spleen B cells assessed as increase in CD40 expression at 10 to 0.1 ug/ml incubated for 24 hrs by fluorescence based flow cytometric analysis | Mus musculus | 6 | ALA5104121 | tissue-based format | Scientific Literature | |
6. | ALA5105461 | B | Agonist activity at TLR2/TLR6 in C57BL/6 mouse spleen dendritic cells assessed as increase in CD40 expression at 10 to 0.1 ug/ml incubated for 24 hrs by fluorescence based flow cytometric analysis | Mus musculus | 6 | ALA5104121 | tissue-based format | Scientific Literature | |
7. | ALA5105469 | F | Immuno-adjuvant activity in C57BL/6 mouse immunized with recombinant influenza A/California/04/2009 HA protein assessed as increase in anti-HAs antibody at 10 ug, IM administered twice 2 weeks apart by ELISA analysis | Mus musculus | 5 | ALA5104121 | organism-based format | Scientific Literature | |
8. | ALA5105470 | F | Protection against influenza A/California/04/2009 virus-challenged C57BL/6 mouse assessed as effect on body weight at 10 ug, IM administered twice 2 weeks apart along with recombinant influenza A/California/04/2009 HA protein immunization | Mus musculus | 5 | ALA5104121 | organism-based format | Scientific Literature | |
9. | ALA5105471 | F | Protection against influenza A/California/04/2009 virus-challenged C57BL/6 mouse assessed as effect on survival at 10 ug, IM administered twice 2 weeks apart along with recombinant influenza A/California/04/2009 HA protein immunization | Mus musculus | 5 | ALA5104121 | organism-based format | Scientific Literature |