| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5149793 | B | Molecular glue activity at HA-tagged CLR4-CRBN/2HA-tagged PXR fused HiBiT-tagged FKBP12 (F36V) mutant (unknown origin) expressed in HepG2 cells assessed as induction of PXR degradation measured after 24 hrs by Nano-Glo HiBiT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 2. | ALA5149812 | B | Induction of PXR degradation in PXR knock in human SNU-C4 cells measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA5149813 | B | Induction of PXR degradation in PXR knock in human SNU-C4 cells at 10 uM measured after 24 hrs in presence of proteasome inhibitor MG-132 by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA5149814 | B | Induction of PXR degradation in PXR knock in human SNU-C4 cells at 10 uM measured after 2 to 48 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA5149815 | F | Down regulation of PXR mRNA expression in PXR knock in human SNU-C4 cells at 10 uM measured after 2 to 48 hrs by RT-qPCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA5149816 | B | Displacement of BODIPY FL vindoline from recombinant human GST-tagged PXR LBD (111 to 434 residues) expressed in baculovirus infected insect cells by TR-FRET assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA5149817 | B | Induction of PXR degradation in PXR knock in human SNU-C4 cells at 5 uM measured after 12 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA5149818 | F | Down regulation of PXR mRNA expression in PXR knock in human SNU-C4 cells at 5 uM measured after 12 hrs by RT-qPCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA5149819 | F | Up regulation of GSPT1 expression in PXR knock in human SNU-C4 cells at 5 uM measured after 12 hrs by TMT-MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA5149820 | F | Up regulation of GSPT2 expression in PXR knock in human SNU-C4 cells at 5 uM measured after 12 hrs by TMT-MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA5149821 | F | Up regulation of ZFP91 expression in PXR knock in human SNU-C4 cells at 5 uM measured after 12 hrs by TMT-MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA5149822 | F | Up regulation of CYP1A1 expression in PXR knock in human SNU-C4 cells at 5 uM measured after 12 hrs by TMT-MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA5149823 | F | Up regulation of BRIP1 expression in PXR knock in human SNU-C4 cells at 5 uM measured after 12 hrs by TMT-MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA5149824 | F | Down regulation of FOS expression in PXR knock in human SNU-C4 cells at 5 uM measured after 12 hrs by TMT-MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA5149825 | B | Induction of GSPT1 degradation in PXR knock in human SNU-C4 cells at 0.001 to 10 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA5149826 | B | Induction of GSPT1 degradation in PXR knock in human SNU-C4 cells at 10 uM measured after 24 hrs in presence of proteasome inhibitor MG-132 by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA5149827 | B | Induction of GSPT1 degradation in PXR knock in human SNU-C4 cells transfected with siCRBN at 0.1 to 10 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA5149829 | F | Cytotoxicity against PXR knock in human SNU-C4 cells measured after 72 hrs by celltiter-glo assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 19. | ALA5149830 | F | Cytotoxicity against PXR knock in human SNU-C4 cells over expressing GSPT1 G575N mutant measured after 72 hrs by celltiter-glo assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 20. | ALA5149831 | B | Induction of GSPT1 degradation in PXR knock in human SNU-C4 cells at 10 uM measured after 24 hrs by Western blot analysis relative to control | Homo sapiens | 13 | cell-based format | Scientific Literature |
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