# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5129518 | Binding | Inhibition of human EGFR (669 to 1210 residues) cytoplasmic domain expressed in baculovirus infected Sf21 cells incubated for 1 hrs in the presence of ATP by mobility shift assay | Homo sapiens | 8 | ALA5126595 | cell-based format | Scientific Literature | |
2. | ALA5129519 | Binding | Inhibition of N-terminal GST-tagged human ceritinib-resistant ALK L1196M mutant (1058 to 1620 residues) cytoplasmic domain expressed in baculovirus infected Sf21 cells incubated for 1 hrs in the presence of ATP by mobility shift assay | Homo sapiens | 8 | ALA5126595 | cell-based format | Scientific Literature | |
3. | ALA5129520 | Functional | Induction of apoptosis in human NCI-H2228 cells assessed as necrotic cells at 50 nM incubated for 48 hrs by AnnexinV-FITC/propidium iodide staining based flow cytometry analysis (Rvb = 0.55 %) | Homo sapiens | 2 | ALA5126595 | cell-based format | Scientific Literature | |
4. | ALA5129521 | Functional | Antiproliferative activity against NPM-ALK positive human KARPAS-299 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay | Homo sapiens | 34 | ALA5126595 | cell-based format | Scientific Literature | |
5. | ALA5129522 | Functional | Antiproliferative activity against EML4-ALK positive human NCI-H2228 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay | Homo sapiens | 34 | ALA5126595 | cell-based format | Scientific Literature | |
6. | ALA5129523 | Functional | Antiproliferative activity against EGFR positive human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay | Homo sapiens | 34 | ALA5126595 | cell-based format | Scientific Literature | |
7. | ALA5129524 | Binding | Inhibition of N-terminal GST-tagged human wild type ALK (1058 to 1620 residues) cytoplasmic domain expressed in baculovirus infected Sf21 cells incubated for 1 hrs in the presence of ATP by mobility shift assay | Homo sapiens | 8 | ALA5126595 | cell-based format | Scientific Literature | |
8. | ALA5129525 | Binding | Inhibition of N-terminal GST-tagged human ceritinib-resistant ALK G1202R mutant (1058 to 1620 residues) cytoplasmic domain expressed in baculovirus infected Sf21 cells incubated for 1 hrs in the presence of ATP by mobility shift assay | Homo sapiens | 8 | ALA5126595 | cell-based format | Scientific Literature | |
9. | ALA5129526 | Functional | Antiproliferative activity human Ba/F3 EML4-ALK cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay | Homo sapiens | 2 | ALA5126595 | cell-based format | Scientific Literature | |
10. | ALA5129527 | Functional | Antiproliferative activity human Ba/F3 EML4-ALK-L1196M cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay | Homo sapiens | 2 | ALA5126595 | cell-based format | Scientific Literature | |
11. | ALA5129528 | Functional | Antiproliferative activity human Ba/F3 EML4-ALK-G1202R cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay | Homo sapiens | 2 | ALA5126595 | cell-based format | Scientific Literature | |
12. | ALA5129529 | Functional | Antiproliferative activity IL3 dependent human Ba/F3 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay | Mus musculus | 2 | ALA5126595 | cell-based format | Scientific Literature | |
13. | ALA5129530 | Functional | Potency index, ratio of test compound IC50 to ceritinib IC50 antiproliferative activity human Ba/F3 EML4-ALK-G1202R cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay | Homo sapiens | 1 | ALA5126595 | cell-based format | Scientific Literature | |
14. | ALA5129531 | Functional | Antiproliferative activity against EML4-ALK positive human NC-H3122 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay | Homo sapiens | 2 | ALA5126595 | cell-based format | Scientific Literature | |
15. | ALA5129532 | Functional | Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay | Homo sapiens | 2 | ALA5126595 | cell-based format | Scientific Literature | |
16. | ALA5129533 | Functional | Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay | Homo sapiens | 2 | ALA5126595 | cell-based format | Scientific Literature | |
17. | ALA5129534 | Functional | Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay | Homo sapiens | 2 | ALA5126595 | cell-based format | Scientific Literature | |
18. | ALA5129535 | Functional | Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay | Homo sapiens | 2 | ALA5126595 | cell-based format | Scientific Literature | |
19. | ALA5129536 | Functional | Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay | Homo sapiens | 2 | ALA5126595 | cell-based format | Scientific Literature | |
20. | ALA5129537 | Functional | Antiproliferative activity against human NC-H1581 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay | Homo sapiens | 2 | ALA5126595 | cell-based format | Scientific Literature |