# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5167405 | A | Volume of distribution at steady state in Sprague-Dawley rat at 0.25 mg/kg, iv bolus injection administered as cassette dose | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
2. | ALA5167406 | A | AUC in Sprague-Dawley rat at 0.25 mg/kg, iv bolus injection administered as cassette dose | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
3. | ALA5167407 | A | Half life in Sprague-Dawley rat at 0.25 mg/kg, iv bolus injection administered as cassette dose | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
4. | ALA5167408 | A | Clearance in Sprague-Dawley rat at 0.25 mg/kg, iv bolus injection administered as cassette dose | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
5. | ALA5167409 | B | Binding affinity to peripheral benzodiazepine receptor (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
6. | ALA5167410 | B | Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells assessed as maximal efficacy at 5 uM in presence of BAM8-22 by Fluo4-dye based FLIPR assay relative to control | Homo sapiens | 61 | cell-based format | Scientific Literature | ||
7. | ALA5167411 | B | Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay | Homo sapiens | 61 | cell-based format | Scientific Literature | ||
8. | ALA5167412 | A | Microsomal stability in human liver microsomes assessed as intrinsic clearance | Homo sapiens | 15 | microsome format | Scientific Literature | ||
9. | ALA5167413 | A | Microsomal stability in mouse liver microsomes assessed as intrinsic clearance | Mus musculus | 15 | microsome format | Scientific Literature | ||
10. | ALA5167414 | A | Plasma protein binding in human assessed as unbound fraction | Homo sapiens | 15 | cell-free format | Scientific Literature | ||
11. | ALA5167415 | A | Plasma protein binding in mouse assessed as unbound fraction | Homo sapiens | 15 | cell-free format | Scientific Literature | ||
12. | ALA5167416 | A | Drug concentration in Sprague-Dawley rat plasma at 0.25 mg/kg measured up to 48.25 hrs | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
13. | ALA5167417 | A | Drug concentration in Sprague-Dawley rat brain at 0.25 mg/kg measured up to 48.25 hrs | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
14. | ALA5167418 | A | Ratio of drug concentration in brain to plasma in Sprague-Dawley rat at 0.25 mg/kg measured after 15 mins | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
15. | ALA5167419 | A | Half life in mouse at 2 mg/kg, ip administered as discrete dose | Mus musculus | 2 | organism-based format | Scientific Literature | ||
16. | ALA5167420 | A | Tmax in mouse at 2 mg/kg, ip administered as discrete dose | Mus musculus | 2 | organism-based format | Scientific Literature | ||
17. | ALA5167421 | A | Cmax in mouse at 2 mg/kg, ip administered as discrete dose | Mus musculus | 2 | organism-based format | Scientific Literature | ||
18. | ALA5167422 | A | AUC in mouse at 2 mg/kg, ip administered as discrete dose | Mus musculus | 2 | organism-based format | Scientific Literature | ||
19. | ALA5167423 | A | Ratio of drug concentration in brain to plasma in mouse at 2 mg/kg, ip administered as discrete dose | Mus musculus | 2 | organism-based format | Scientific Literature | ||
20. | ALA5167424 | B | Binding affinity to D5 receptor (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature |