| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5144081 | B | Inhibition of full length FLAG/HA/Strep-tagged TLK2 (unknown origin) transfected in HEK293T cells assessed as reduction in TLK mediated ASF1a phosphorylation at 50 uM by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 2. | ALA5144083 | B | Inhibition of full length FLAG/HA/Strep-tagged TLK2 (unknown origin) in human U2OS cells assessed as ASF1 phosphorylation by measuring decrease in band shift at 16.7 uM measured after 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA5144084 | B | Inhibition of full length FLAG/HA/Strep-tagged TLK2 (unknown origin) in human MDA-MB-231 cells assessed as reduction in ASF1 phosphorylation at 16.7 uM measured after 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA5144086 | F | Effect on cell cycle progression in human U2OS cells assessed as accumulation of cells at S phase measured after 8 hrs by PI staining based flow cytometric analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA5144087 | F | Inhibition of DNA replication in PCNA positive human U2OS cells assessed as reduction in EdU level at 2.5 to 20 uM incubated for 4 hrs by immunofluorescence staining based EdU incorporation assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA5144089 | F | Induction of DNA damage in human U2OS cells assessed as increase in CHK1 phosphorylation at S345 residue at 2.5 to 5 uM incubated for 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA5144090 | F | Induction of DNA damage in human U2OS cells assessed as increase in CHK2 phosphorylation at T68 residue at 5 to 10 uM incubated for 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA5144091 | F | Induction of DNA damage in human U2OS cells assessed as increase in KAP1 phosphorylation at S824 residue at 5 to 10 uM incubated for 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA5144092 | F | Induction of DNA damage in human U2OS cells assessed as increase in RPA2 phosphorylation at S4/S8 residue at 5 to 10 uM incubated for 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA5144093 | F | Induction of DNA damage in PCNA positive human U2OS cells assessed as increase in H2AX phosphorylation at S139 residue in S phase by measuring fluorescence intensity at 10 uM incubated for 4 hrs by immunofluorescence microscopy | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA5144094 | B | Inhibition of ASF1a phosphorylation at S166 residue in human MDA-MB-231 cells at 10 uM incubated for 4 hrs by Western blot analysis | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 12. | ALA5144096 | F | Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability at 0.5 uM measured after 72 hrs by MTT assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 13. | ALA5144097 | B | Binding affinity to full length FLAG/HA/Strep-tagged TLK2 (388 to 772 residues) (unknown origin) transfected in HEK293T cells by Alexa Fluor 647 staining based FRET assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 14. | ALA5144110 | F | Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 15. | ALA5144111 | F | Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 16. | ALA5144112 | F | Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 17. | ALA5144113 | T | Cytotoxicity against human IMR-90 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 18. | ALA5144114 | T | Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 5 | cell-based format | Scientific Literature |
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