# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5136719 | A | Metabolic stability in rat liver microsomes assessed as intrinsic clearance at 10 uM preincubated for 5 mins followed by NADPH addition and measured upto 65 mins by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA5131569 | microsome format | Scientific Literature | |
2. | ALA5136720 | B | Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamate-induced channel current at -70 mV holding potential by whole cell patch clamp method | Homo sapiens | 22 | ALA5131569 | cell-based format | Scientific Literature | |
3. | ALA5136721 | B | Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamate-induced channel current at -70 mV holding potential by whole cell patch clamp method relative to control | Homo sapiens | 17 | ALA5131569 | cell-based format | Scientific Literature | |
4. | ALA5136722 | B | Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamate-induced channel current at -70 mV holding potential by whole cell patch clamp method | Homo sapiens | 20 | ALA5131569 | cell-based format | Scientific Literature | |
5. | ALA5136723 | B | Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamate-induced channel current at -70 mV holding potential by whole cell patch clamp method relative to control | Homo sapiens | 16 | ALA5131569 | cell-based format | Scientific Literature | |
6. | ALA5136724 | P | Lipophilicity, logD of compound in MeOH at 20 uM by HPLC analysis | 4 | ALA5131569 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA5136725 | P | Aqueous solubility of compound in PBS incubated for 1 hr under shaking condition by HPLC-MS/MS analysis | 4 | ALA5131569 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA5136726 | A | Metabolic stability in mouse liver microsomes assessed as intrinsic clearance at 10 uM preincubated for 5 mins followed by NADPH addition and measured upto 65 mins by LC-MS/MS analysis | Mus musculus | 4 | ALA5131569 | microsome format | Scientific Literature | |
9. | ALA5136727 | A | Metabolic stability in human liver microsomes assessed as clearance at 10 uM preincubated for 5 mins followed by NADPH addition and measured upto 65 mins by LC-MS/MS analysis | Homo sapiens | 4 | ALA5131569 | microsome format | Scientific Literature | |
10. | ALA5136728 | A | Metabolic stability in rat liver microsomes assessed as clearance at 10 uM preincubated for 5 mins followed by NADPH addition and measured upto 65 mins by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA5131569 | microsome format | Scientific Literature | |
11. | ALA5136729 | A | Metabolic stability in mouse liver microsomes assessed as clearance at 10 uM preincubated for 5 mins followed by NADPH addition and measured upto 65 mins by LC-MS/MS analysis | Mus musculus | 4 | ALA5131569 | microsome format | Scientific Literature | |
12. | ALA5136736 | A | Metabolic stability in dog liver microsomes assessed as intrinsic clearance at 10 uM preincubated for 5 mins followed by NADPH addition and measured upto 65 mins by LC-MS/MS analysis | Canis lupus familiaris | 4 | ALA5131569 | microsome format | Scientific Literature | |
13. | ALA5136737 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance at 10 uM preincubated for 5 mins followed by NADPH addition and measured upto 65 mins by LC-MS/MS analysis | Homo sapiens | 4 | ALA5131569 | microsome format | Scientific Literature | |
14. | ALA5136738 | A | Clearance in CD-1 mouse by LC-MS/MS analysis | Mus musculus | 4 | ALA5131569 | assay format | Scientific Literature | |
15. | ALA5136739 | A | Clearance in Sprague-Dawley rat by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA5131569 | assay format | Scientific Literature | |
16. | ALA5136740 | A | Clearance in Beagle dog by LC-MS/MS analysis | Canis lupus familiaris | 4 | ALA5131569 | assay format | Scientific Literature | |
17. | ALA5136741 | A | Oral bioavailability in CD-1 mouse by LC-MS/MS analysis | Mus musculus | 4 | ALA5131569 | organism-based format | Scientific Literature | |
18. | ALA5136742 | A | Oral bioavailability in Sprague-Dawley rat by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA5131569 | organism-based format | Scientific Literature | |
19. | ALA5136743 | A | Oral bioavailability in Beagle dog by LC-MS/MS analysis | Canis lupus familiaris | 4 | ALA5131569 | organism-based format | Scientific Literature | |
20. | ALA5136744 | A | Ratio of drug concentration in ip dosed CD-1 mouse brain to plasma after 1 hr by LC-MS/MS analysis | Mus musculus | 4 | ALA5131569 | organism-based format | Scientific Literature |