| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5140066 | B | Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by ATP addition and measured after 30 mins by ELISA | Mus musculus | 29 | cell-based format | Scientific Literature | ||
| 2. | ALA5140067 | T | Cytotoxicity against mouse J774.A1 cells assessed as cell viability at 10 uM incubated for 4 hrs by MTT assay relative to control | Mus musculus | 29 | cell-based format | Scientific Literature | ||
| 3. | ALA5140068 | T | Cytotoxicity against HEK293 cells assessed as cell viability at 10 uM incubated for 4 hrs by MTT assay relative to control | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
| 4. | ALA5140069 | B | Inhibition of NLRC4 inflammasome in LPS-primed mouse J774.A1 cells assessed as IL-1beta secretion at 10 uM preincubated for 1 hr followed by flagellin addition and measured after 6 hrs by ELISA relative to control | Mus musculus | 15 | cell-based format | Scientific Literature | ||
| 5. | ALA5140070 | B | Inhibition of AIM2 inflammasome in LPS-primed mouse J774.A1 cells assessed as IL-1beta secretion at 10 uM preincubated for 1 hr followed by poly(dA:dT) addition and measured after 4 hrs by ELISA relative to control | Mus musculus | 15 | cell-based format | Scientific Literature | ||
| 6. | ALA5140071 | B | Inhibition of NLRC4 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr followed by flagellin addition and measured after 6 hrs by ELISA | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 7. | ALA5140072 | B | Inhibition of AIM2 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr followed by poly(dA:dT) addition and measured after 4 hrs by ELISA | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 8. | ALA5140073 | F | Inhibition of IL-6 production in LPS-primed mouse J774.A1 cells at 0.3 to 30 uM pretreated with compounds for 30 mins followed by LPS addition and measured after 16 hrs by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA5140074 | F | Inhibition of TNF-alpha production in LPS-primed mouse J774.A1 cells at 0.3 to 30 uM pretreated with compounds for 30 mins followed by LPS addition and measured after 16 hrs by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA5140075 | B | Inhibition of NLRP3 inflammasome in LPS-primed mouse BMDM cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by ATP addition and measured after 30 mins by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA5140076 | B | Binding affinity to human recombinant full length NLRP3 transfected in HEK293F cells assessed as dissociation constant incubated for 40 mins by microscale thermophoresis analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA5140077 | F | Inhibition of IL-1beta production in C57BL/6 mouse assessed as reduction in IL-1beta level in serum at 10 mg/kg, ip pretreated with compound followed by LPS addition and measured after 2.5 hrs by ELISA | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA5140078 | F | Inhibition of TNF-alpha production in C57BL/6 mouse assessed as reduction in TNF-alpha level in serum at 10 mg/kg, ip pretreated with compound followed by LPS addition and measured after 2.5 hrs by ELISA | Mus musculus | 1 | organism-based format | Scientific Literature |
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