# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5138538 | B | Inhibition of human recombinant full-length DNMT1 expressed in Sf9 cells assessed as inhibition of methylated dI-dC formation using poly dI-dC and [Me-3H]SAM as substrate incubated for 2 hrs by liquid scintillation counting analysis | Homo sapiens | 18 | ALA5137006 | cell-based format | Scientific Literature | |
2. | ALA5138551 | B | Inhibition of DNMT1 in human HT-29 cells assessed as reduction of 5-methylcytosine in cellular DNA at 40 uM incubated for 96 hrs by nLC-MS analysis | Homo sapiens | 2 | ALA5137006 | cell-based format | Scientific Literature | |
3. | ALA5138553 | B | Inhibition of human C-terminal domain DNMT3b catalytic domain (568 to 853 residues) expressed in Escherichia coli BL21 (DE3) pLysS cells assessed as inhibition of methylated dI-dC formation using poly dI-dC and [Me-3H]SAM as substrate at 100 uM incubated for 45 mins in presence of DNMT3L by liquid scintillation counting analysis | Homo sapiens | 1 | ALA5137006 | cell-based format | Scientific Literature |