| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5138944 | B | Inhibition of human full length recombinant GST-tagged PRMT1 (2 to 371 residues) using histone H4 as substrate incubated for 20 mins in presence of [3H]-SAM by radioisotope-based filter assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 2. | ALA5138945 | B | Inhibition of human full length recombinant GST his-tagged PRMT3 (2 to 531 residues) using histone H4 as substrate incubated for 20 mins in presence of [3H]-SAM by radioisotope-based filter assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 3. | ALA5138946 | B | Inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate incubated for 20 mins in presence of [3H]-SAM by radioisotope-based filter assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 4. | ALA5138947 | B | Inhibition of human full length recombinant FLAG-tagged PRMT5 (2 to 637 residues) using histone H2A as substrate incubated for 20 mins in presence of [3H]-SAM by radioisotope-based filter assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 5. | ALA5138948 | B | Inhibition of human full length recombinant GST-tagged PRMT6 (2 to 375 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]-SAM by radioisotope-based filter assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 6. | ALA5138949 | B | Inhibition of human full length recombinant his-tagged PRMT7 (2 to 692 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]-SAM by radioisotope-based filter assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 7. | ALA5138950 | B | Inhibition of human full length recombinant his-tagged PRMT8 (61 to 394 residues) using histone H4 as substrate incubated for 20 mins in presence of [3H]-SAM by radioisotope-based filter assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 8. | ALA5138951 | B | Selectivity index, ratio of IC50 for inhibition of human full length recombinant GST-tagged PRMT1 (2 to 371 residues) using histone H4 as substrate to IC50 for inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 9. | ALA5138952 | B | Selectivity index, ratio of IC50 for inhibition of human full length recombinant GST his-tagged PRMT3 (2 to 531 residues) using histone H4 as substrate to IC50 for inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 10. | ALA5138953 | B | Selectivity index, ratio of IC50 for inhibition of human full length recombinant FLAG-tagged PRMT5 (2 to 637 residues) using histone H2A as substrate to IC50 for inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 11. | ALA5138954 | B | Selectivity index, ratio of IC50 for inhibition of human full length recombinant GST-tagged PRMT6 (2 to 375 residues) using GST-GAR as substrate to IC50 for inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 12. | ALA5138955 | B | Selectivity index, ratio of IC50 for inhibition of human full length recombinant his-tagged PRMT7 (2 to 692 residues) using GST-GAR as substrate to IC50 for inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 13. | ALA5138956 | B | Selectivity index, ratio of IC50 for human full length recombinant his-tagged PRMT8 (61 to 394 residues) using histone H4 as substrate to IC50 for inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 14. | ALA5138957 | B | Inhibition of N-terminal His-tagged recombinant human ASH1L (2046 to 2330 residues) at 1 to 10 uM incubated for 60 mins in presence of [3H]-SAM by hotspot assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 15. | ALA5138958 | B | Inhibition of recombinant human EZH2 (2 to 746 residues) at 1 to 10 uM incubated for 60 mins in presence of [3H]-SAM by hotspot assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 16. | ALA5138959 | B | Inhibition of recombinant human his-tagged MLL1 (3745 to 3969residues) at 1 to 10 uM incubated for 60 mins in presence of [3H]-SAM by hotspot assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 17. | ALA5138960 | B | Inhibition of recombinant human his-tagged SET7/9 (2 to 366 residues) at 1 to 10 uM incubated for 60 mins in presence of [3H]-SAM by hotspot assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 18. | ALA5138961 | B | Inhibition of recombinant human his-tagged SETD8 (190 to 352 residues) at 1 to 10 uM incubated for 60 mins in presence of [3H]-SAM by hotspot assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 19. | ALA5138962 | B | Inhibition of DOT1L (unknown origin) at 1 to 10 uM incubated for 60 mins in presence of [3H]-SAM by hotspot assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 20. | ALA5138963 | B | Binding affinity to full length recombinant PRMT4 (unknown origin) assessed as dissociation constant by surface plasmon resonance | Homo sapiens | 9 | single protein format | Scientific Literature |
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