# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5118350 | F | Sleep inducing activity in C57BL/6J mouse assessed as decrease in total time of wakefulness during dark phase at 10 mg/kg, ip measured at 12 to 18 hrs by EEG/EMG analysis | Mus musculus | 1 | ALA5113495 | organism-based format | Scientific Literature | |
2. | ALA5118351 | F | Sleep inducing activity in C57BL/6J mouse assessed as increase in total time of NREM sleep during dark phase at 10 mg/kg, ip measured at 12 to 18 hrs by EEG/EMG analysis | Mus musculus | 1 | ALA5113495 | organism-based format | Scientific Literature | |
3. | ALA5118352 | F | Antagonist activity at human OX1R expressed in CHO-K1 cells assessed as inhibition of orexin-A-induced increase in calcium mobilization preincubated for 15 mins followed orexin-A stimulation by Fura-2-AM dye based fluorescence assay | Homo sapiens | 26 | ALA5113495 | cell-based format | Scientific Literature | |
4. | ALA5118353 | F | Antagonist activity at human OX2R expressed in CHO-K1 cells assessed as inhibition of orexin-A-induced increase in calcium mobilization preincubated for 15 mins followed orexin-A stimulation by Fura-2-AM dye based fluorescence assay | Homo sapiens | 26 | ALA5113495 | cell-based format | Scientific Literature | |
5. | ALA5118355 | A | Apparent permeability across apical to basolateral side in human Caco-2 cells at pH 7.4 in the presence of 1% BSA | Homo sapiens | 2 | ALA5113495 | cell-based format | Scientific Literature | |
6. | ALA5118359 | A | Efflux ratio of apparent permeability across basolateral to apical over apical to basolateral side in human Caco-2 cells at pH 7.4 in the presence of 1% BSA | Homo sapiens | 1 | ALA5113495 | cell-based format | Scientific Literature | |
7. | ALA5118362 | A | Metabolic stability in pooled human liver microsomes assessed as intrinsic clearance at 10 mg/ml preincubated for 5 mins followed by NADPH addition and measured upto 60 mins by HPLC-MS/MS analysis | Homo sapiens | 2 | ALA5113495 | microsome format | Scientific Literature | |
8. | ALA5118363 | A | Metabolic stability in pooled human liver microsomes assessed as half-life at 10 mg/ml preincubated for 5 mins followed by NADPH addition and measured upto 60 mins by HPLC-MS/MS analysis | Homo sapiens | 2 | ALA5113495 | microsome format | Scientific Literature | |
9. | ALA5118364 | A | Drug concentration in C57BL/6J mouse brain at 10 mg/kg, ip measured after 0.5 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA5113495 | organism-based format | Scientific Literature | |
10. | ALA5118368 | B | Displacement of [3H]-DAMGO from human mu opioid receptor expressed in HEK cell by microbeta scintillation counting method | Homo sapiens | 2 | ALA5113495 | cell-based format | Scientific Literature | |
11. | ALA5118369 | B | Displacement of [3H]-DPDPE from human delta opioid receptor expressed in HEK cell by microbeta scintillation counting method | Homo sapiens | 2 | ALA5113495 | cell-based format | Scientific Literature | |
12. | ALA5118370 | B | Displacement of [3H]-U69593from human kappa opioid receptor expressed in HEK cell by microbeta scintillation counting method | Homo sapiens | 2 | ALA5113495 | cell-based format | Scientific Literature | |
13. | ALA5133615 | F | Antagonist activity at human OX1R expressed in CHO-K1 cells assessed as inhibition of orexin-A-induced increase in calcium mobilization preincubated for 15 mins followed orexin-A stimulation by by Fura-2-AM dye based fluorescence assay | Homo sapiens | 2 | ALA5131434 | cell-based format | Scientific Literature | |
14. | ALA5243959 | B | Antagonist activity at OX1R (unknown origin) | Homo sapiens | 2 | ALA5241129 | single protein format | Scientific Literature | |
15. | ALA5243960 | B | Antagonist activity at OX2R (unknown origin) | Homo sapiens | 1 | ALA5241129 | single protein format | Scientific Literature |