# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5118238 | Binding | Inhibition of HDAC7 (unknown origin) using fluorogenic substrate incubated for 30 mins by fluorescence plate reader | Homo sapiens | 2 | ALA5113492 | single protein format | Scientific Literature | |
2. | ALA5118239 | Binding | Inhibition of HDAC6 (unknown origin) using fluorogenic substrate incubated for 30 mins by fluorescence plate reader | Homo sapiens | 5 | ALA5113492 | single protein format | Scientific Literature | |
3. | ALA5118240 | Binding | Inhibition of His-tagged N-terminal recombinant HSP90alpha (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 4 hrs by fluorescence polarization based microplate reader assay | Homo sapiens | 11 | ALA5113492 | assay format | Scientific Literature | |
4. | ALA5118241 | Functional | Antiproliferative activity against human NCI-H1975 cells assessed as growth inhibition incubated upto 72 hrs by CellTiter96 Aqueous One Solution Cell Proliferation assay | Homo sapiens | 11 | ALA5113492 | cell-based format | Scientific Literature | |
5. | ALA5118242 | Binding | Inhibition of HDAC1 (unknown origin) using fluorogenic substrate incubated for 30 mins by fluorescence plate reader | Homo sapiens | 5 | ALA5113492 | single protein format | Scientific Literature | |
6. | ALA5118243 | Binding | Inhibition of HDAC3 (unknown origin) using fluorogenic substrate incubated for 30 mins by fluorescence plate reader | Homo sapiens | 2 | ALA5113492 | single protein format | Scientific Literature | |
7. | ALA5118244 | Binding | Selectivity index, ratio of IC50 for HDAC1 (unknown origin) to IC50 for HDAC6 (unknown origin) | Homo sapiens | 2 | ALA5113492 | assay format | Scientific Literature | |
8. | ALA5118245 | Binding | Selectivity index, ratio of IC50 for HDAC3 (unknown origin) to IC50 for HDAC6 (unknown origin) | Homo sapiens | 2 | ALA5113492 | assay format | Scientific Literature | |
9. | ALA5118246 | Binding | Selectivity index, ratio of IC50 for HDAC7 (unknown origin) to IC50 for HDAC6 (unknown origin) | Homo sapiens | 2 | ALA5113492 | assay format | Scientific Literature | |
10. | ALA5118247 | Binding | Inhibition of HSP90 in human NCI-H1975 cells assessed as downregulation of Her2 expression at 0.05 to 2 uM incubated for 24 hrs by western blot analysis | Homo sapiens | 1 | ALA5113492 | cell-based format | Scientific Literature | |
11. | ALA5118248 | Binding | Inhibition of HSP90 in human NCI-H1975 cells assessed as downregulation of EGFR expression at 0.05 to 2 uM incubated for 24 hrs by western blot analysis | Homo sapiens | 1 | ALA5113492 | cell-based format | Scientific Literature | |
12. | ALA5118249 | Binding | Inhibition of HSP90 in human NCI-H1975 cells assessed as downregulation of Met expression at 0.05 to 2 uM incubated for 24 hrs by western blot analysis | Homo sapiens | 1 | ALA5113492 | cell-based format | Scientific Literature | |
13. | ALA5118250 | Binding | Inhibition of HSP90 in human NCI-H1975 cells assessed as downregulation of Akt expression at 0.05 to 2 uM incubated for 24 hrs by western blot analysis | Homo sapiens | 1 | ALA5113492 | cell-based format | Scientific Literature | |
14. | ALA5118251 | Binding | Inhibition of HSP90 in human NCI-H1975 cells assessed as upregulation of HSP70 expression at 0.05 to 2 uM incubated for 24 hrs by western blot analysis | Homo sapiens | 1 | ALA5113492 | cell-based format | Scientific Literature | |
15. | ALA5118252 | Binding | Inhibition of HSP90 in human NCI-H1975 cells assessed as downregulation of HSP90 expression at 0.05 to 2 uM incubated for 24 hrs by western blot analysis | Homo sapiens | 1 | ALA5113492 | cell-based format | Scientific Literature | |
16. | ALA5118253 | Binding | Inhibition of HDAC6 in human NCI-H1975 cells assessed as downregulation of HDAC6 expression at 0.05 to 2 uM incubated for 24 hrs by western blot analysis | Homo sapiens | 1 | ALA5113492 | cell-based format | Scientific Literature | |
17. | ALA5118254 | Binding | Inhibition of HDAC6 in human NCI-H1975 cells assessed as increase in acetylation of alpha tubulin at 1 uM incubated for 24 hrs by western blot analysis | Homo sapiens | 2 | ALA5113492 | cell-based format | Scientific Literature | |
18. | ALA5118255 | Binding | Inhibition of HDAC6 in human NCI-H1975 cells assessed as effect on alpha tubulin expression at 0.05 to 2 uM incubated for 24 hrs by western blot analysis | Homo sapiens | 1 | ALA5113492 | cell-based format | Scientific Literature | |
19. | ALA5118257 | Binding | Inhibition of HSP90 in human NCI-H1975 cells assessed as downregulation of Her2 expression at 2 uM incubated for 24 hrs by western blot analysis | Homo sapiens | 3 | ALA5113492 | cell-based format | Scientific Literature | |
20. | ALA5118258 | Binding | Inhibition of HSP90 in human NCI-H1975 cells assessed as downregulation of EGFR expression at 2 uM incubated for 24 hrs by western blot analysis | Homo sapiens | 3 | ALA5113492 | cell-based format | Scientific Literature |