# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5100323 | B | Inhibition of N-terminal His-Avi tagged recombinant human FGFR3 (447 to 761 residues) expressed in an Sf9 infected baculovirus expression system using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by substrate addition and measured after 1 hr by HTRF assay | Homo sapiens | 30 | cell-based format | Scientific Literature | ||
2. | ALA5100325 | B | Inhibition of recombinant human FGFR1 using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by substrate addition and measured after 1 hr by HTRF assay | Homo sapiens | 29 | single protein format | Scientific Literature | ||
3. | ALA5100327 | B | Inhibition of TEL-FGFR3 in mouse BaF3 cells incubated for 125 mins by plate reader analysis | Mus musculus | 14 | cell-based format | Scientific Literature | ||
4. | ALA5100328 | B | Inhibition of wild type partial length human FLT3 (V592 to Y969 residues) expressed in bacterial expression system using Ulight-p70S6K peptide substrate incubated for 90 mins in presence of ATP by HTRF assay | Homo sapiens | 8 | assay format | Scientific Literature | ||
5. | ALA5100329 | B | Inhibition of wild type partial length human TRKA (G475 to G790 residues) expressed in mammalian expression system using Ulight-p70S6K peptide substrate incubated for 90 mins in presence of ATP by HTRF assay | Homo sapiens | 8 | assay format | Scientific Literature | ||
6. | ALA5100330 | B | Inhibition of wild type partial length human KIT (I571 to D952 residues) expressed in bacterial expression system using Ulight-p70S6K peptide substrate incubated for 90 mins in presence of ATP by HTRF assay | Homo sapiens | 8 | assay format | Scientific Literature | ||
7. | ALA5100331 | B | Inhibition of wild type partial length human PDGFRbeta (V582 to Y1009 residues) expressed in bacterial expression system using Ulight-p70S6K peptide substrate incubated for 90 mins in presence of ATP by HTRF assay | Homo sapiens | 8 | assay format | Scientific Literature | ||
8. | ALA5100332 | A | Apparent permeability in human Caco-2 cells at 50 uM incubated for 120 mins by LC-MS/MS analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
9. | ALA5100333 | A | Metabolic stability in human liver microsomes assessed as clearance at 1 uM preincubated for 2 mins followed by NADPH addition and measured upto 30 mins by LC-MS/MS analysis | Homo sapiens | 4 | microsome format | Scientific Literature | ||
10. | ALA5100334 | P | Solubility of compound in FaSSIF by HPLC assay | 3 | small-molecule physicochemical format | Scientific Literature | |||
11. | ALA5100335 | P | Solubility of compound in SGF by HPLC assay | 3 | small-molecule physicochemical format | Scientific Literature | |||
12. | ALA5100336 | B | Inhibition of human liver microsomes CYP3A4 using midazolam or testosterone as substrate in presence of NADPH regenerating system by LC-MS/MS analysis | Homo sapiens | 6 | microsome format | Scientific Literature | ||
13. | ALA5100337 | A | Clearance in Sprague-Dawley rat assessed as hepatic blood flow at 0.73 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
14. | ALA5100338 | A | Volume of distribution at steady state in Sprague-Dawley rat at 0.73 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
15. | ALA5100339 | A | Half life in Sprague-Dawley rat at 0.73 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
16. | ALA5100340 | A | Cmax in Sprague-Dawley rat at 3.1 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
17. | ALA5100341 | A | AUC in Sprague-Dawley rat at 3.1 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
18. | ALA5100342 | A | Oral bioavailability in Sprague-Dawley rat at 3.1 mg/kg measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature |