| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5130996 | P | Stability of compound in buffer at pH 7.4 | 1 | ALA5126645 | small-molecule physicochemical format | Scientific Literature | ||
| 2. | ALA5130997 | B | Inhibition of LSD1 (unknown origin) using H3K4me2 peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by fluorescence based analysis | Homo sapiens | 7 | ALA5126645 | single protein format | Scientific Literature | |
| 3. | ALA5130998 | B | Potency index, ratio of phenylcyclopropylamine IC50 to test compound IC50 for inhibition of LSD1 (unknown origin) using H3K4me2 peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by fluorescence based analysis | Homo sapiens | 1 | ALA5126645 | single protein format | Scientific Literature | |
| 4. | ALA5130999 | A | Prodrug conversion assessed as LSD1 (unknown origin)-mediated vorinostat release incubated for 24 hrs by HPLC analysis | Homo sapiens | 2 | ALA5126645 | single protein format | Scientific Literature | |
| 5. | ALA5131000 | A | Prodrug conversion assessed as FAD (unknown origin)-mediated vorinostat release incubated for 24 hrs by HPLC analysis | Homo sapiens | 2 | ALA5126645 | assay format | Scientific Literature | |
| 6. | ALA5131001 | F | Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 3 days by alamar blue assay | Homo sapiens | 7 | ALA5126645 | cell-based format | Scientific Literature | |
| 7. | ALA5131002 | F | Antiproliferative activity against human NCI-H526 cells assessed as inhibition of cell growth incubated for 3 days by alamar blue assay | Homo sapiens | 7 | ALA5126645 | cell-based format | Scientific Literature | |
| 8. | ALA5131003 | T | Cytotoxicity against HMEC cells assessed as inhibition of cell growth incubated for 3 days by alamar blue assay | Homo sapiens | 7 | ALA5126645 | cell-based format | Scientific Literature | |
| 9. | ALA5131004 | T | Selectivity index, ratio of IC50 for cytotoxicity against HMEC cells to GI50 for antiproliferative activity against human MDA-MB-231 cells | Homo sapiens | 7 | ALA5126645 | cell-based format | Scientific Literature | |
| 10. | ALA5131005 | T | Selectivity index, ratio of IC50 for cytotoxicity against HMEC cells to GI50 for antiproliferative activity against human NCI-H526 cells | Homo sapiens | 7 | ALA5126645 | cell-based format | Scientific Literature |
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