| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5133037 | P | Aqueous solubility of compound in pH 7.4 PBS buffer measured after 24 hrs by LC-MS/MS analysis | 4 | small-molecule physicochemical format | Scientific Literature | |||
| 2. | ALA5133038 | F | Inhibition of TNF-alpha/LTD4 induced cell adhesion in human U-937 cells assessed as reduction in cell adhesion to HAEC cells at 10 uM incubated for 26 hrs by BCECF-AM fluorescence based microplate reader assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 3. | ALA5133041 | P | Lipophilicity, logD of the compound in octanol and phosphate buffer at pH 7.4 incubated for 2 hrs under shaking condition by LC-MS/MS analysis | 4 | small-molecule physicochemical format | Scientific Literature | |||
| 4. | ALA5133042 | A | Metabolic stability in human liver microsomes assessed as half life at 1 uM measured up to 60 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 4 | microsome format | Scientific Literature | ||
| 5. | ALA5133043 | A | Metabolic stability in human liver microsomes assessed as Intrinsic clearance at 1 uM measured up to 60 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 4 | microsome format | Scientific Literature | ||
| 6. | ALA5133044 | A | Metabolic stability in human liver S9 fraction assessed as half life at 1 uM measured after 2 hrs in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 4 | subcellular format | Scientific Literature | ||
| 7. | ALA5133045 | A | Metabolic stability in human liver S9 fraction assessed as Intrinsic clearance at 1 uM measured after 2 hrs in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 4 | subcellular format | Scientific Literature | ||
| 8. | ALA5133046 | F | Antagonist activity against human CysLT1 expressed in CHO cells assessed as inhibition of LTD4 induced cytosolic Calcium ion mobilization at 10 uM measured after 75 mins by Fluo4 dye based fluorimetric microplate reader assay relative to control | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
| 9. | ALA5133047 | F | Antagonist activity against human CysLT1 expressed in CHO cells assessed as inhibition of LTD4 induced cytosolic Calcium ion mobilization measured after 75 mins by Fluo4 dye based fluorimetric microplate reader assay relative to control | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
| 10. | ALA5133048 | F | Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element by measuring maximum efficacy at 10 uM incubated for 18 hrs by luciferase assay based luminometer analysis | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
| 11. | ALA5133049 | F | Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
| 12. | ALA5133050 | F | Anti-inflammatory activity in mouse RAW264.7 cells assessed as as decrease in LPS-induced TNF-alpha expression at 0.1 to 10 uM measured after 16 hrs by RT-PCR analysis | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 13. | ALA5133051 | F | Antiproliferation activity against LTD4 induced mouse RAW264.7 cells incubated for 48 hrs by Trypan blue staining based MTS assay | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 14. | ALA5133052 | F | Anti-inflammatory activity against TNF-alpha/LTD4 induced human U-937 cells assessed as decrease in expression of IL-1beta expression at 10 uM by RT-qPCR analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 15. | ALA5133053 | F | Anti-inflammatory activity against TNF-alpha/LTD4 induced human U-937 cells assessed as decrease in expression of TNF-alpha expression at 10 uM by RT-qPCR analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 16. | ALA5133054 | F | Anti-inflammatory activity against TNF-alpha/LTD4 induced human U-937 cells assessed as decrease in expression of CCL2 expression at 10 uM by RT-qPCR analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 17. | ALA5133055 | F | Anti-inflammatory activity in mouse RAW264.7 cells assessed as as decrease in LPS-induced IL-1beta expression at 0.1 to 10 uM measured after 16 hrs by RT-PCR analysis | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 18. | ALA5133056 | F | Anti-inflammatory activity in mouse RAW264.7 cells assessed as as increase in LPS-induced IL-10 expression at 0.1 to 10 uM measured after 16 hrs by RT-PCR analysis | Mus musculus | 3 | cell-based format | Scientific Literature |
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