| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5167052 | A | Metabolic stability in rat liver microsomes assessed as half life at 1 uM preincubated for 10 mins followed by NADPH addition and measured after 30 mins by LC/MS/MS analysis | Rattus norvegicus | 6 | microsome format | Scientific Literature | ||
| 2. | ALA5167053 | B | Inhibition of human recombinant full length GST-tagged p38alpha expressed in Escherichia coli preincubated for 2 hrs followed by ATP addition and measured after 1 hr by Alpha screen assay | Homo sapiens | 43 | assay format | Scientific Literature | ||
| 3. | ALA5167054 | F | Inhibition of LPS-stimulated TNFalpha release in human PBMC cells preincubated for 1 hr followed by LPS stimulation and measured after 18 hrs | Homo sapiens | 44 | cell-based format | Scientific Literature | ||
| 4. | ALA5167055 | B | Displacement of SKF-86002 from human inactivated p38alpha assessed as dissociation half life incubated for 2 hrs by fluorescence based analysis | Homo sapiens | 43 | single protein format | Scientific Literature | ||
| 5. | ALA5167056 | B | Inhibition of recombinant human full length His-tagged p38beta expressed in baculovirus expression system preincubated for 2 hrs followed by ATP addition and measured after 1 hr by Alpha screen assay | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 6. | ALA5167057 | B | Inhibition of recombinant human full length His-tagged p38gamma expressed in baculovirus expression system preincubated for 2 hrs followed by ATP addition and measured after 1 hr by Alpha screen assay | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 7. | ALA5167058 | B | Inhibition of recombinant human full length His-tagged p38delta expressed in baculovirus expression system preincubated for 2 hrs followed by ATP addition and measured after 1 hr by Alpha screen assay | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 8. | ALA5167059 | P | Solubility of the compound at >=1 mg/ml measured after 30 mins by HPLC analysis | 6 | small-molecule physicochemical format | Scientific Literature | |||
| 9. | ALA5167060 | A | Permeability across apical to basolateral side in human Caco-2 cells at 10 uM measured after 60 mins by LC/MS/MS analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 10. | ALA5167062 | A | Protein binding in rat plasma at 10 uM incubated for 4 hrs by LC/MS/MS analysis | Rattus norvegicus | 6 | cell-free format | Scientific Literature | ||
| 11. | ALA5167063 | A | Protein binding in rat lung homogenate at 10 uM incubated for 4 hrs by LC/MS/MS analysis | Rattus norvegicus | 6 | tissue-based format | Scientific Literature | ||
| 12. | ALA5167069 | A | Selectivity index, ratio of drug concentration in Sprague-Dawley rat lung homogenate to IC50 for human p38alpha | 6 | tissue-based format | Scientific Literature | |||
| 13. | ALA5167070 | A | Drug uptake in Sprague-Dawley rat lung homogenate at 0.03 mg/kg, IT measured after 7 hrs by LC/MS/MS analysis | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
| 14. | ALA5167072 | A | Drug uptake in Sprague-Dawley rat lung homogenate at 0.03 mg/kg, IT measured after 24 hrs by LC/MS/MS analysis | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
| 15. | ALA5167073 | A | Efflux ratio of permeability in human Caco-2 cells at 10 uM measured after 60 mins by LC-MS/MS analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 16. | ALA5167075 | A | Drug concentration in Sprague-Dawley rat lung homogenate at 0.3 mg/kg, IT measured after 24 hrs by LC/MS/MS analysis | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
| 17. | ALA5167076 | A | Cmax in Sprague-Dawley rat lung homogenate at 0.3 mg/kg, IT measured after 0.8 hrs by LC/MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 18. | ALA5167077 | A | Cmax in Sprague-Dawley rat plasma at 0.3 mg/kg, IT measured after 0.8 hrs by LC/MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 19. | ALA5167078 | F | Antiinflammatory activity against LPS-induced Sprague-Dawley rat inflammatory model assessed as inhibition of neutrophil cells release in BALF at 0.3 mg/kg, IT incubated for 9 hrs followed by LPS-stimulation relative to control | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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