| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5153561 | B | Inhibition of HDAC8 in human Jurkat T cells assessed as upregulation of IL23 expression after 6 hrs by RT-qPCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA5153562 | B | Inhibition of recombinant human HDAC1 using p53 (Ac-RHKK(Acetyl)-AMC) as substrate preincubated for 5 mins followed by substrate addition and measured after 90 mins by fluorescence based analysis | Homo sapiens | 19 | single protein format | Scientific Literature | ||
| 3. | ALA5153563 | B | Inhibition of recombinant human HDAC2 using p53 (Ac-RHKK(Acetyl)-AMC) as substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by fluorescence based analysis | Homo sapiens | 19 | single protein format | Scientific Literature | ||
| 4. | ALA5153564 | B | Inhibition of recombinant human HDAC3 using p53 (Ac-RHKK(Acetyl)-AMC) as substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by fluorescence based analysis | Homo sapiens | 24 | single protein format | Scientific Literature | ||
| 5. | ALA5153565 | B | Inhibition of recombinant human HDAC8 using (Abz-SRGK(thio-TFA)FFRR-NH2) as substrate preincubated for 5 mins followed by substrate addition by fluorescence based analysis | Homo sapiens | 17 | single protein format | Scientific Literature | ||
| 6. | ALA5153566 | B | Inhibition of HDAC4 (unknown origin) | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 7. | ALA5153567 | B | Inhibition of recombinant human HDAC6 (unknown origin) | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 8. | ALA5153568 | B | Inhibition of recombinant human HDAC11 preincubated for 10 mins followed by substrate addition by fluorescence based analysis | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 9. | ALA5153577 | B | Inhibition of human sirtuin2 using p53 (Ac-RHKK(Acetyl)-AMC) as substrate preincubated for 5 mins followed by substrate addition and measured after 120 mins in presence of NAD+ by fluorescence based assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 10. | ALA5153578 | B | Inhibition of human sirtuin2 using p53 (Ac-RHKK(Myristoyl)-AMC) as substrate preincubated for 5 mins followed by substrate addition and measured after 120 mins in presence of NAD+ by fluorescence based assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 11. | ALA5153579 | B | Competitive inhibition of human HDAC8 using Abz-SRGGK(STFA)FFRR-NH2 (S) as substrate by Lineweaver-burk plot analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 12. | ALA5153580 | B | Reversible binding affinity to recombinant human HDAC8 incubated for 30 mins by jump dilution method | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 13. | ALA5153581 | P | Stability of compound in DMEM/DMSO/acetonitrile at pH 7.4 measured after 6 hrs by HPLC analysis | 3 | small-molecule physicochemical format | Scientific Literature | |||
| 14. | ALA5153582 | P | Stability of compound in DMEM/DMSO/acetonitrile at pH 7.4 measured after 12 hrs by HPLC analysis | 3 | small-molecule physicochemical format | Scientific Literature | |||
| 15. | ALA5153583 | P | Stability of compound in DMEM/DMSO/acetonitrile at pH 7.4 measured after 24 hrs by HPLC analysis | 3 | small-molecule physicochemical format | Scientific Literature | |||
| 16. | ALA5153584 | P | Stability of compound in DMEM/DMSO/acetonitrile at pH 7.4 measured after 48 hrs by HPLC analysis | 3 | small-molecule physicochemical format | Scientific Literature | |||
| 17. | ALA5153585 | P | Stability of compound in DMEM/DMSO/acetonitrile at pH 7.4 measured after 72 hrs by HPLC analysis | 3 | small-molecule physicochemical format | Scientific Literature | |||
| 18. | ALA5153586 | T | Cytotoxicity against HEK293 cells assessed as reduction in cell viability at 50 uM after 24 hrs by alamar blue assay | Homo sapiens | 26 | cell-based format | Scientific Literature | ||
| 19. | ALA5153587 | B | Inhibition of HDAC8 in human Jurkat T cells assessed as increase in H3K27 acetylation at 10 uM after 6 hrs by Western blot analysis | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 20. | ALA5153588 | B | Inhibition of HDAC8 in human Jurkat T cells assessed as upregulation of BCL6 expression at 10 uM after 6 to 12 hrs by RT-qPCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |
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