| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5099154 | B | Binding affinity to S1PR2 (unknown origin) assessed as dissociation constant by surface plasmon resonance analysis | Homo sapiens | 41 | ALA5096216 | single protein format | Scientific Literature | |
| 2. | ALA5121094 | B | Binding affinity to S1PR2 (unknown origin) by SPR assay | Homo sapiens | 34 | ALA5120746 | single protein format | Scientific Literature | |
| 3. | ALA5121095 | F | Reversal of 5-FU resistance against 5-FU resistant DPD expressed human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs in presence of 5-FU by MTT assay | Homo sapiens | 34 | ALA5120746 | cell-based format | Scientific Literature | |
| 4. | ALA5121096 | F | Reversal of 5-FU resistance against human SW620/5-FU cells assessed as reduction in cell viability incubated for 48 hrs in presence of 5-FU by MTT assay | Homo sapiens | 34 | ALA5120746 | cell-based format | Scientific Literature | |
| 5. | ALA5121097 | T | Cytotoxicity against human NCM460 cells assessed as reduction in cell viability at 5 to 80 uM | Homo sapiens | 1 | ALA5120746 | cell-based format | Scientific Literature | |
| 6. | ALA5121098 | T | Cytotoxicity against human NCM460 cells assessed as reduction in cell viability at 5 to 80 uM in presence of 5-fluorouracil | Homo sapiens | 1 | ALA5120746 | cell-based format | Scientific Literature | |
| 7. | ALA5121099 | F | Downregulation of DPD expression level in human SW620/5-FU cells measured after 12 hrs by Western blot analysis | Homo sapiens | 1 | ALA5120746 | cell-based format | Scientific Literature | |
| 8. | ALA5121100 | F | Downregulation of DPD expression in DPD expressed human HCT-116 cells measured after 12 hrs by Western blot analysis | Homo sapiens | 1 | ALA5120746 | cell-based format | Scientific Literature | |
| 9. | ALA5121101 | F | Downregulation of DPD expression in human SW620/5-FU cells at 10 uM by Western blot analysis | Homo sapiens | 1 | ALA5120746 | cell-based format | Scientific Literature | |
| 10. | ALA5121102 | B | Reversal of Pgp-mediated paclitaxel resistance in human LCC6MDR cells assessed as P-gp modulating activity by measuring relative fold at 1 uM | Homo sapiens | 1 | ALA5120746 | cell-based format | Scientific Literature | |
| 11. | ALA5121103 | F | Downregulation of S1PR2 mRNA expression level in human SW620/5-FU cells at 20 uM measured after 24 hrs by qRT-PCR analysis | Homo sapiens | 1 | ALA5120746 | cell-based format | Scientific Literature | |
| 12. | ALA5121104 | F | Downregulation of S1PR2 mRNA expression level in DPD expressed human HCT-116 cells at 20 uM measured after 24 hrs by qRT-PCR analysis | Homo sapiens | 1 | ALA5120746 | cell-based format | Scientific Literature | |
| 13. | ALA5121105 | F | Antagonist activity at S1PR2 in human SW620/5-FU cells assessed as reduction of DPD-catalyzed 5-FU degradation by measuring intracellular 5-FU level at 20 uM measured after 24 hrs by HPLC-UV analysis (Rvb = 2.57 uM) | Homo sapiens | 2 | ALA5120746 | cell-based format | Scientific Literature | |
| 14. | ALA5121106 | A | Initial drug concentration in Sprague-Dawley rat blood at 1 mg/kg, iv measured up to 24 hrs by HPLC-MS/MS analysis | Rattus norvegicus | 1 | ALA5120746 | organism-based format | Scientific Literature | |
| 15. | ALA5121107 | A | Half life in Sprague-Dawley rat blood at 1 mg/kg, iv measured up to 24 hrs by HPLC-MS/MS analysis | Rattus norvegicus | 1 | ALA5120746 | organism-based format | Scientific Literature | |
| 16. | ALA5121108 | A | AUC (0 to t) in Sprague-Dawley rat blood at 1 mg/kg, iv measured up to 24 hrs by HPLC-MS/MS analysis | Rattus norvegicus | 1 | ALA5120746 | organism-based format | Scientific Literature | |
| 17. | ALA5121109 | A | AUC (0 to infinity) in Sprague-Dawley rat blood at 1 mg/kg, iv measured up to 24 hrs by HPLC-MS/MS analysis | Rattus norvegicus | 1 | ALA5120746 | organism-based format | Scientific Literature | |
| 18. | ALA5121110 | A | Apparent volume of distribution in Sprague-Dawley rat blood at 1 mg/kg, iv measured up to 24 hrs by HPLC-MS/MS analysis | Rattus norvegicus | 1 | ALA5120746 | organism-based format | Scientific Literature | |
| 19. | ALA5121111 | A | Clearance in Sprague-Dawley rat blood at 1 mg/kg, iv measured up to 24 hrs by HPLC-MS/MS analysis | Rattus norvegicus | 1 | ALA5120746 | organism-based format | Scientific Literature | |
| 20. | ALA5121112 | A | MRT (0 to t) in Sprague-Dawley rat blood at 1 mg/kg, iv measured up to 24 hrs by HPLC-MS/MS analysis | Rattus norvegicus | 1 | ALA5120746 | organism-based format | Scientific Literature |
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