| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5166476 | B | Displacement of [3H]HOCPCA from CaMK2alpha in rat brain cerebral cortex membrane homogenates assessed as inhibition constant measured after 60 mins by TopCount scintillation counting method | Rattus norvegicus | 4 | cell membrane format | Scientific Literature | ||
| 2. | ALA5166477 | A | Apparent permeability across apical to basolateral side in dog MDCKII-MDR1 cells at 3 uM measured after 60 to 90 mins by LC-MS/MS analysis | Canis lupus familiaris | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA5166478 | B | Displacement of [3H]NCS-382 from CaMK2alpha in rat brain cerebral cortex membrane homogenates assessed as inhibition constant measured after 60 mins by TopCount scintillation counting method | Rattus norvegicus | 21 | cell membrane format | Scientific Literature | ||
| 4. | ALA5166479 | B | Displacement of [3H]HOCPCA from recombinant full length CaMK2alpha (unknown origin) expressed in HEK293 cell homogenates assessed as inhibition constant measured after 60 mins by liquid scintillation counting method | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA5166482 | A | Plasma concentration in C57BL/6J mouse at 5 mg/kg , sc measured after 30 mins by UPLC based tandem mass spectrometry analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 6. | ALA5166488 | B | Binding affinity to recombinant human CaMK2alpha (345 to 475 residues) expressed in Escherichia coli BL21 DE3 assessed as thermal stability by measuring change in melting temperature at 160 uM by SYPRO orange dye based differential scanning fluorimetry | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 7. | ALA5166490 | P | Chemical stability of compound in PBS buffer at pH 7.4 assessed as half life at 25 degreeC incubated for 7 days by HPLC based LC-MS analysis | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 8. | ALA5166491 | P | Chemical stability of compound in PBS buffer at pH 7.4 assessed as half life at 37 degreeC incubated for 7 days by HPLC based LC-MS analysis | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 9. | ALA5166496 | A | Brain concentration in C57BL/6J mouse at 5 mg/kg , sc measured after 30 mins by UPLC based tandem mass spectrometry analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA5166498 | A | Ratio of drug concentration in brain to plasma in C57BL/6J mouse at 5 mg/kg , sc measured after 30 mins by UPLC based tandem mass spectrometry analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA5166500 | A | Apparent permeability across basolateral to apical side in dog MDCKII-MDR1 cells at 3 uM measured after 60 to 90 mins by LC-MS/MS analysis | Canis lupus familiaris | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA5166501 | A | Apparent permeability across apical to basolateral side in dog MDCK-II cells expressing BCRP at 3 uM measured after 60 to 90 mins by LC-MS/MS analysis | Canis lupus familiaris | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA5166502 | A | Apparent permeability across basolateral to apical side in dog MDCK-II cells expressing BCRP at 3 uM measured after 60 to 90 mins by LC-MS/MS analysis | Canis lupus familiaris | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA5166503 | A | Apparent permeability across apical to basolateral side in dog MDCK-II cells expressing BCRP at 3 uM preincubated with BCRP inhibitor, Ko 143 for 15 to 30 mins followed by compound addition and measured after 60 to 90 mins by LC-MS/MS analysis | Canis lupus familiaris | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA5166504 | A | Apparent permeability across basolateral to apical side in dog MDCK-II cells expressing BCRP at 3 uM preincubated with BCRP inhibitor, Ko 143 for 15 to 30 mins followed by compound addition and measured after 60 to 90 mins by LC-MS/MS analysis | Canis lupus familiaris | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA5166505 | A | Apparent permeability across apical to basolateral side in dog MDCKII-MDR1 cells at 3 uM preincubated with P-gp inhibitor elacridar for 15 to 30 mins followed by compound addition and measured after 60 to 90 mins by LC-MS/MS analysis | Canis lupus familiaris | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA5166506 | A | Apparent permeability across basolateral to apical side in dog MDCKII-MDR1 cells at 3 uM preincubated with P-gp inhibitor elacridar for 15 to 30 mins followed by compound addition and measured after 60 to 90 mins by LC-MS/MS analysis | Canis lupus familiaris | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA5166507 | A | Efflux ratio of apparent permeability from basolateral to apical side over apical to basolateral side in dog MDCK-II cells expressing BCRP at 3 uM measured after 60 to 90 mins by LC-MS/MS analysis | Canis lupus familiaris | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA5166508 | A | Efflux ratio of apparent permeability from basolateral to apical side over apical to basolateral side in dog MDCK-II cells expressing BCRP at 3 uM preincubated with BCRP inhibitor, Ko 143 for 15 to 30 mins followed by compound addition and measured after 60 to 90 mins by LC-MS/MS analysis | Canis lupus familiaris | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA5166509 | A | Efflux ratio of apparent permeability from basolateral to apical side over apical to basolateral side in dog MDCKII-MDR1 cells at 3 uM measured after 60 to 90 mins by LC-MS/MS analysis | Canis lupus familiaris | 1 | cell-based format | Scientific Literature |
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