| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5156860 | A | Drug metabolism in Sprague-Dawley rat hepatocytes assessed as oxidized metabolite M2 formation at 10 uM measured after 60 mins by LC-MS/MS analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA5156861 | A | Prodrug conversion in rat liver S9 fraction assessed as DH5FU metabolite formation at 1.6 mM incubated for 1 hr in presence of NADPH by 19F-NMR based analysis | Rattus norvegicus | 1 | subcellular format | Scientific Literature | ||
| 3. | ALA5156862 | A | Tmax in male Wistar Han rat at 10 mg/kg, po administered as single dose measured upto 24 hrs | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 4. | ALA5156863 | A | Prodrug conversion in PBS buffer assessed as 5-Fluorouracil formation by measuring retention time at 100 uM in presence of Pd-resin measured upto 1 hr by UPLC analysis | 1 | assay format | Scientific Literature | |||
| 5. | ALA5156864 | F | Antiproliferative activity against human BxPC-3 cells assessed as reduction in cell viability measured after 5 days by PrestoBlue reagent based assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA5156865 | F | Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability measured after 5 days by PrestoBlue reagent based assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 7. | ALA5156866 | F | Antiproliferative activity against human BxPC-3 cells assessed as increase in cytotoxicity at 1 uM incubated for 5 days in presence of Pd-resin by PrestoBlue dye based assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA5156867 | F | Antiproliferative activity against human HCT-116 cells assessed as increase in cytotoxicity at 1 uM incubated for 5 days in presence of Pd-resin by PrestoBlue dye based assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA5156868 | F | Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability at 100 uM incubated for 5 days in presence of Pd-resins at 0.8 mg/ml by PrestoBlue dye based assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 10. | ALA5156869 | A | Prodrug conversion in human liver S9 fraction assessed as DH5FU metabolite formation at 1.6 mM incubated for 1 hr in presence of NADPH by 19F-NMR based analysis | Homo sapiens | 3 | subcellular format | Scientific Literature | ||
| 11. | ALA5156870 | A | Metabolic stability in rat hepatocytes assessed as intrinsic clearance at 3 uM measured per 10^6 cells by LC-MS/MS analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA5156871 | A | Metabolic stability in rat hepatocytes assessed as intrinsic clearance at 1 uM measured per 10^6 cells by LC-MS/MS analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA5156872 | A | Metabolic stability in human hepatocytes assessed as intrinsic clearance at 1 uM measured per 10^6 cells by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA5156873 | A | Metabolic stability in rat hepatocytes assessed as half life at 3 uM by LC-MS/MS analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA5156874 | A | Metabolic stability in rat hepatocytes assessed as half life at 1 uM by LC-MS/MS analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA5156875 | A | Metabolic stability in human hepatocytes assessed as half life at 1 uM by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA5156876 | A | Apparent permeability across apical to basolateral side in human Caco-2 cells at 10 uM measured after 120 mins by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA5156877 | A | Apparent permeability across basolateral to apical side in human Caco-2 cells at 10 uM measured after 120 mins by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA5156878 | A | Apparent permeability across apical to basolateral side in human Caco-2 cells assessed as drug recovery at 10 uM measured after 120 mins by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA5156879 | A | Apparent permeability across basolateral to apical side in human Caco-2 cells assessed as drug recovery at 10 uM measured after 120 mins by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |
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