# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5148523 | B | Displacement of [3H]ZM241385 from human A2AAR expressed in HEK293 cells membrane assessed as inhibition constant preincubated for 5 mins followed by [3H]ZM241385 addition and measured after 1.5 hrs by TopCount scintillation counting method | Homo sapiens | 29 | cell membrane format | Scientific Literature | ||
2. | ALA5148524 | B | Displacement of [3H]DPCPX from human A1AR expressed in HEK293 cells membrane assessed as inhibition constant preincubated for 5 mins followed by [3H]DPCPX addition and measured after 1.5 hrs by TopCount scintillation counting method | Homo sapiens | 29 | cell membrane format | Scientific Literature | ||
3. | ALA5148526 | B | Selectivity ratio of Ki for human A1AR expressed in HEK293 cells membrane to Ki for human A2AAR expressed in HEK293 cells membrane | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
4. | ALA5148527 | B | Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cells membrane assessed as inhibition constant preincubated for 5 mins followed by [3H]DPCPX addition and measured after 1.5 hrs by TopCount scintillation counting method | Homo sapiens | 3 | cell membrane format | Scientific Literature | ||
5. | ALA5148528 | B | Displacement of [3H]HEMADO from human A3AR expressed in CHO-K1 cells membrane assessed as inhibition constant preincubated for 5 mins followed by [3H]HEMADO addition and measured after 1.5 hrs by TopCount scintillation counting method | Homo sapiens | 3 | cell membrane format | Scientific Literature | ||
6. | ALA5148543 | F | Antagonist activity at A2AAR in human HEK293 cells assessed as inhibition of CGS21680-induced cAMP production preincubated for 15 mins followed by CGS21680 addition and measured after 15 mins by HTRF assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
7. | ALA5148544 | F | Antagonist activity at A2AAR in human T -cells assessed as increase in IL-2 production preincubated for 1 hr followed by CD3/CD28 monoclonal antibody addition and measured after 24 hrs in presence of NECA by ELISA | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
8. | ALA5148562 | P | Water solubility of compound | 2 | small-molecule physicochemical format | Scientific Literature | |||
9. | ALA5148563 | F | Antagonist activity at A2AAR in human T -cells assessed as fold increase in IL-2 production preincubated for 1 hr followed by CD3/CD28 addition and measured after 24 hrs in presence of NECA by ELISA | Homo sapiens | 4 | cell-based format | Scientific Literature |