# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5123640 | F | Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 7 days by MTT assay | Homo sapiens | 6 | ALA5120857 | cell-based format | Scientific Literature | |
2. | ALA5123641 | F | Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 7 days by MTT assay | Homo sapiens | 6 | ALA5120857 | cell-based format | Scientific Literature | |
3. | ALA5123642 | F | Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 7 days by MTT assay | Homo sapiens | 6 | ALA5120857 | cell-based format | Scientific Literature | |
4. | ALA5123643 | T | Cytotoxicity against mouse AML12 cells assessed as reduction in cell viability incubated for 7 days by MTT assay | Mus musculus | 6 | ALA5120857 | cell-based format | Scientific Literature | |
5. | ALA5123644 | B | Inhibition of PARP-1 (unknown origin) using biotinylated NAD+ as substrate at 10 nM incubated for 45 mins in the presence of deoxy-oligonucleotide by microplate reader method relative to control | Homo sapiens | 13 | ALA5120857 | single protein format | Scientific Literature | |
6. | ALA5123645 | B | Inhibition of TNKS1 (unknown origin) using biotin-NAD+ as substrate at 10 nM incubated for 1 hr in the presence of deoxy-oligonucleotide by ELISA analysis relative to control | Homo sapiens | 13 | ALA5120857 | single protein format | Scientific Literature | |
7. | ALA5123646 | B | Inhibition of TNKS2 (unknown origin) using biotin-NAD+ as substrate at 10 nM incubated for 1 hr in the presence of deoxy-oligonucleotide by ELISA analysis relative to control | Homo sapiens | 13 | ALA5120857 | single protein format | Scientific Literature | |
8. | ALA5123647 | B | Inhibition of PARP-1 (unknown origin) using biotinylated NAD+ as substrate incubated for 45 mins in the presence of deoxy-oligonucleotide by microplate reader method relative to control | Homo sapiens | 10 | ALA5120857 | single protein format | Scientific Literature | |
9. | ALA5123648 | B | Inhibition of TNKS1 (unknown origin) using biotin-NAD+ as substrate incubated for 1 hr in the presence of deoxy-oligonucleotide by ELISA analysis relative to control | Homo sapiens | 11 | ALA5120857 | single protein format | Scientific Literature | |
10. | ALA5123649 | B | Inhibition of TNKS2 (unknown origin) using biotin-NAD+ as substrate incubated for 1 hr in the presence of deoxy-oligonucleotide by ELISA analysis relative to control | Homo sapiens | 11 | ALA5120857 | single protein format | Scientific Literature | |
11. | ALA5123650 | B | Inhibition of Wnt/beta-Catenin signaling in human HCT-116 cells assessed as increase in axin2 levels at 10 uM by Western blot analysis | Homo sapiens | 4 | ALA5120857 | cell-based format | Scientific Literature | |
12. | ALA5123651 | B | Inhibition of Wnt/beta-Catenin signaling in human HCT-116 cells assessed as decrease in active beta-catenin levels at 10 uM by Western blot analysis | Homo sapiens | 2 | ALA5120857 | cell-based format | Scientific Literature | |
13. | ALA5123652 | B | Inhibition of Wnt/beta-Catenin signaling in human HCT-116 cells assessed as decrease in total beta-catenin levels at 10 uM by Western blot analysis | Homo sapiens | 2 | ALA5120857 | cell-based format | Scientific Literature | |
14. | ALA5123653 | B | Inhibition of Wnt/beta-Catenin signaling in human HCT-116 cells assessed as decrease in cyclin D1 levels at 10 uM by Western blot analysis | Homo sapiens | 4 | ALA5120857 | cell-based format | Scientific Literature | |
15. | ALA5123654 | B | Inhibition of PARP in human HCT-116 cells assessed as decrease in pADPr levels at 10 uM by Western blot analysis | Homo sapiens | 4 | ALA5120857 | cell-based format | Scientific Literature | |
16. | ALA5123655 | F | Downregulation of BRCA1 protein expression in human HCT-116 cells at 1 uM by Western blot analysis | Homo sapiens | 1 | ALA5120857 | cell-based format | Scientific Literature | |
17. | ALA5123656 | F | Inhibition of homologous recombinant repair in human HCT-116 cells assessed as reduction in RAD51 foci formation at 1 uM incubated for 72 hrs by DAPI staining based immunofluorescence analysis | Homo sapiens | 1 | ALA5120857 | cell-based format | Scientific Literature | |
18. | ALA5123657 | F | Induction of DNA damage in human HCT-116 cells assessed as increase in nuclear gammaH2AX foci incubated for 72 hrs by DAPI staining based immunofluorescence analysis | Homo sapiens | 1 | ALA5120857 | cell-based format | Scientific Literature | |
19. | ALA5123658 | F | Induction of apoptosis in human HCT-116 cells assessed as viable cells at 5 uM incubated for 3 days by annexinV-FITC/propidium iodide staining based flow cytometry (Rvb = 60.0 %) | Homo sapiens | 3 | ALA5120857 | cell-based format | Scientific Literature | |
20. | ALA5123659 | F | Induction of apoptosis in human HCT-116 cells assessed as early apoptotic cells at 5 uM incubated for 3 days by annexinV-FITC/propidium iodide staining based flow cytometry (Rvb = 7.67 %) | Homo sapiens | 3 | ALA5120857 | cell-based format | Scientific Literature |