# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5132795 | Binding | Inhibition of FLAG-tagged full-length human recombinant DYRK1A (127 to 485 residues) expressed in Escherichia coli assessed as reduction in autophosphorylation at Ser97 residue by Western blot analysis | Homo sapiens | 12 | ALA5131396 | assay format | Scientific Literature | |
2. | ALA5132796 | Binding | Inhibition of FLAG-tagged full-length human recombinant DYRK1A (127 to 485 residues) expressed in Escherichia coli assessed as reduction in phosphorylated tyrosine level by Western blot analysis | Homo sapiens | 2 | ALA5131396 | assay format | Scientific Literature | |
3. | ALA5132797 | Binding | Inhibition of FLAG-tagged full-length human recombinant DYRK1A (127 to 485 residues) expressed in Escherichia coli assessed as reduction in substrate peptide phosphorylation at 32 uM using DYRKtide peptide as substrate incubated for 45 mins in presence of ATP by Kinase-Glo Luminescent kinase assay | Homo sapiens | 13 | ALA5131396 | assay format | Scientific Literature | |
4. | ALA5132798 | Binding | Inhibition of FLAG-tagged full-length human recombinant DYRK1A (127 to 485 residues) expressed in Escherichia coli assessed as reduction in TAU intermolecular phosphorylation incubated for 30 mins by Western blot analysis | Homo sapiens | 2 | ALA5131396 | assay format | Scientific Literature | |
5. | ALA5132799 | Toxicity | Cytotoxicity against HEK293 cells up to 8 uM | Homo sapiens | 2 | ALA5131396 | cell-based format | Scientific Literature | |
6. | ALA5132800 | Binding | Induction of degradation of endogenous FLAG-tagged full-length human recombinant DYRK1A (127 to 485 residues) expressed in Escherichia coli in HEK293 cells assessed as decrease in protein level measured after 4 days by Western blot analysis | Homo sapiens | 1 | ALA5131396 | cell-based format | Scientific Literature | |
7. | ALA5132802 | Binding | Inhibition of PKD1 in HEK293 cells at 1 to 2 uM measured after 4 days by Western blot analysis | Homo sapiens | 1 | ALA5131396 | cell-based format | Scientific Literature | |
8. | ALA5132803 | Binding | Inhibition of ROCK1 in HEK293 cells at 1 to 2 uM measured after 4 days by Western blot analysis | Homo sapiens | 1 | ALA5131396 | cell-based format | Scientific Literature | |
9. | ALA5132804 | Binding | Inhibition of recombinant PKD1 in HEK293 cells at 32 uM using DYRKtide peptide as substrate incubated for 45 mins in presence of ATP by Kinase-Glo Luminescent kinase assay | Homo sapiens | 2 | ALA5131396 | cell-based format | Scientific Literature | |
10. | ALA5132805 | Binding | Inhibition of recombinant ROCK1 in HEK293 cells at 32 uM using DYRKtide peptide as substrate incubated for 45 mins in presence of ATP by Kinase-Glo Luminescent kinase assay | Homo sapiens | 2 | ALA5131396 | cell-based format | Scientific Literature | |
11. | ALA5132806 | Binding | Inhibition of HSP90 in HEK293 cells up to 8 uM measured after 4 days by Western blot analysis | Homo sapiens | 2 | ALA5131396 | cell-based format | Scientific Literature | |
12. | ALA5132807 | Binding | Inhibition of CDC37 in HEK293 cells up to 8 uM measured after 4 days by Western blot analysis | Homo sapiens | 2 | ALA5131396 | cell-based format | Scientific Literature | |
13. | ALA5132808 | Binding | Inhibition of FYN in HEK293 cells up to 8 uM measured after 4 days by Western blot analysis | Homo sapiens | 2 | ALA5131396 | cell-based format | Scientific Literature | |
14. | ALA5132809 | Binding | Inhibition of MSK1 in HEK293 cells up to 8 uM measured after 4 days by Western blot analysis | Homo sapiens | 2 | ALA5131396 | cell-based format | Scientific Literature |