| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5157524 | F | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 4330 after 16 to 18 hrs by microbroth dilution method | Staphylococcus aureus | 19 | ALA5154694 | organism-based format | Scientific Literature | |
| 2. | ALA5157526 | F | Bactericidal activity against methicillin-resistant Staphylococcus aureus ATCC 4330 assessed as reduction in bacterial counts at 2X MIC within 0.5 hrs by time-kill kinetic assay | Staphylococcus aureus | 9 | ALA5154694 | organism-based format | Scientific Literature | |
| 3. | ALA5157527 | F | Bactericidal activity against methicillin-resistant Staphylococcus aureus ATCC 4330 assessed as reduction in bacterial counts at 4X MIC by time-kill kinetic assay | Staphylococcus aureus | 9 | ALA5154694 | organism-based format | Scientific Literature | |
| 4. | ALA5157528 | F | Bactericidal activity against methicillin-resistant Staphylococcus aureus ATCC 4330 assessed as reduction in bacterial counts at 1 to 4X MIC within 24 hrs by time-kill kinetic assay | Staphylococcus aureus | 9 | ALA5154694 | organism-based format | Scientific Literature | |
| 5. | ALA5157530 | F | Bactericidal activity against methicillin-resistant Staphylococcus aureus ATCC 4330 assessed as inhibition of bacterial regrowth at 2X MIC after 24 hrs by time-kill kinetic assay | Staphylococcus aureus | 6 | ALA5154694 | organism-based format | Scientific Literature | |
| 6. | ALA5157531 | T | Hemolytic activity in mouse erythrocytes assessed as hemolysis at 12.5 ug/ml relative to control | Mus musculus | 4 | ALA5154694 | cell-based format | Scientific Literature | |
| 7. | ALA5157532 | T | Cytotoxicity against mouse RAW264.7 cells assessed as cell survival at 12.5 ug/ml incubated for 24 hrs by CCK-8 assay | Mus musculus | 3 | ALA5154694 | cell-based format | Scientific Literature | |
| 8. | ALA5157533 | T | Cytotoxicity against mouse RAW264.7 cells assessed as cell survival at 25 ug/ml incubated for 24 hrs by CCK-8 assay | Mus musculus | 3 | ALA5154694 | cell-based format | Scientific Literature | |
| 9. | ALA5157534 | T | Cytotoxicity against mouse RAW264.7 cells assessed as cell survival at 50 ug/ml incubated for 24 hrs by CCK-8 assay | Mus musculus | 4 | ALA5154694 | cell-based format | Scientific Literature | |
| 10. | ALA5157535 | F | Induction of membrane morphological changes in methicillin-resistant Staphylococcus aureus ATCC 4330 assessed as visible cell surface wrinkles at 4X MIC after 2 hrs by scanning electron microscopy | Staphylococcus aureus | 4 | ALA5154694 | assay format | Scientific Literature | |
| 11. | ALA5157536 | F | Induction of membrane morphological changes in methicillin-resistant Staphylococcus aureus ATCC 4330 assessed as visible cell filaments at 4X MIC after 2 hrs by scanning electron microscopy | Staphylococcus aureus | 4 | ALA5154694 | assay format | Scientific Literature | |
| 12. | ALA5157537 | F | Induction of membrane morphological changes in methicillin-resistant Staphylococcus aureus ATCC 4330 assessed as visible cell membrane disruption at 4X MIC after 2 hrs by transmission electron microscopy | Staphylococcus aureus | 4 | ALA5154694 | assay format | Scientific Literature | |
| 13. | ALA5157538 | F | Induction of membrane morphological changes in methicillin-resistant Staphylococcus aureus ATCC 4330 assessed as visible cell wall fragments at 4X MIC after 2 hrs by transmission electron microscopy | Staphylococcus aureus | 4 | ALA5154694 | assay format | Scientific Literature | |
| 14. | ALA5157539 | F | Induction of membrane morphological changes in methicillin-resistant Staphylococcus aureus ATCC 4330 assessed as ghost cells at 4X MIC after 2 hrs by transmission electron microscopy | Staphylococcus aureus | 4 | ALA5154694 | assay format | Scientific Literature | |
| 15. | ALA5157541 | F | Induction of membrane morphological changes in methicillin-resistant Staphylococcus aureus ATCC 4330 assessed as fluorescent intensity at 1 to 4X MIC measured after 30 to 120 mins by propidium iodide staining based flow cytometry assay | Staphylococcus aureus | 2 | ALA5154694 | assay format | Scientific Literature | |
| 16. | ALA5157542 | B | Inhibition of methicillin-resistant Staphylococcus aureus ATCC 4330 genomic DNA migration at 3.125 to 6.25 ug/ml measured by electrophoretic mobility assay | Staphylococcus aureus | 4 | ALA5154694 | nucleic acid format | Scientific Literature | |
| 17. | ALA5157543 | B | Binding affinity to methicillin-resistant Staphylococcus aureus ATCC 4330 DNA assessed as induction of confirmational changes at 50 ug/ml measured by Circular dichroism assay | Staphylococcus aureus | 4 | ALA5154694 | nucleic acid format | Scientific Literature | |
| 18. | ALA5157546 | F | Antibiofilm activity against methicillin-resistant Staphylococcus aureus ATCC 4330 assessed as inhibition of biofilm formation at 1.56 ug/ml after 24 hrs by crystal violet staining based assay relative to control | Staphylococcus aureus | 2 | ALA5154694 | organism-based format | Scientific Literature | |
| 19. | ALA5157547 | F | Antibiofilm activity against methicillin-resistant Staphylococcus aureus ATCC 4330 assessed as fold change in downregulation of RSH mRNA expression at 4X MIC after 2 hrs by qRT-PCR assay | Staphylococcus aureus | 4 | ALA5154694 | organism-based format | Scientific Literature | |
| 20. | ALA5157548 | F | Antibiofilm activity against methicillin-resistant Staphylococcus aureus ATCC 4330 assessed as fold change in downregulation of relP mRNA expression at 4X MIC after 2 hrs by qRT-PCR assay | Staphylococcus aureus | 4 | ALA5154694 | organism-based format | Scientific Literature |
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