# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5136569 | A | Clearance in Balb/C mouse plasma at 10 mg/kg, iv measured upto 48 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA5131564 | organism-based format | Scientific Literature | |
2. | ALA5136570 | F | Inhibition of LPS/MDP-stimulated TNFalpha production in C57BL/6J mouse BMDM cells by ELISA relative to control | Mus musculus | 5 | ALA5131564 | cell-based format | Scientific Literature | |
3. | ALA5136575 | A | Metabolic stability in human liver microsomes assessed as half life at 1 uM by LC/MS/MS analysis | Homo sapiens | 20 | ALA5131564 | microsome format | Scientific Literature | |
4. | ALA5136576 | A | Metabolic stability in human liver microsomes assessed as clearance at 1 uM by LC/MS/MS analysis | Homo sapiens | 20 | ALA5131564 | microsome format | Scientific Literature | |
5. | ALA5136578 | T | Toxicity in rat H9c2 cells assessed as inhibitory rate | Rattus norvegicus | 6 | ALA5131564 | cell-based format | Scientific Literature | |
6. | ALA5136579 | F | Anti-inflammatory activity against DSS-induced acute ulcerative colitis C57BL/6 mouse model assessed as recovery of weight loss at 20 mg/kg, po for 6 consecutive days | Mus musculus | 3 | ALA5131564 | organism-based format | Scientific Literature | |
7. | ALA5136580 | T | Cytotoxicity against mouse RAW264.7 cells at 62.5 to 250 nM in presence of NOD measured after 24 hrs by propidium iodide staining based flow cytometry | Mus musculus | 1 | ALA5131564 | cell-based format | Scientific Literature | |
8. | ALA5136581 | T | Cytotoxicity against mouse BMDM cells at 62.5 to 250 nM in presence of NOD | Mus musculus | 1 | ALA5131564 | cell-based format | Scientific Literature | |
9. | ALA5136582 | F | Inhibition of MDP-stimulated TNFalpha production in mouse RAW264.7 cells assessed as TNFalpha mRNA level upto 50 nM incubated for 22 hrs by real-time PCR analysis | Mus musculus | 1 | ALA5131564 | cell-based format | Scientific Literature | |
10. | ALA5136583 | F | Inhibition of MDP-stimulated TNFalpha production in C57BL/6J mouse BMDM cells at 1 uM measured after 24 hrs by ELISA | Mus musculus | 1 | ALA5131564 | cell-based format | Scientific Literature | |
11. | ALA5136584 | F | Inhibition of LPS-stimulated TNFalpha production in C57BL/6J mouse BMDM cells at 1 uM measured after 24 hrs by ELISA | Mus musculus | 1 | ALA5131564 | cell-based format | Scientific Literature | |
12. | ALA5136585 | F | Inhibition of Nig-stimulated TNFalpha production in C57BL/6J mouse BMDM cells at 1 uM measured after 24 hrs by ELISA | Mus musculus | 1 | ALA5131564 | cell-based format | Scientific Literature | |
13. | ALA5136586 | F | Inhibition of ATP-stimulated TNFalpha production in C57BL/6J mouse BMDM cells at 1 uM measured after 24 hrs by ELISA | Mus musculus | 1 | ALA5131564 | cell-based format | Scientific Literature | |
14. | ALA5136587 | F | Inhibition of Alum-stimulated TNFalpha production in C57BL/6J mouse BMDM cells at 1 uM measured after 24 hrs by ELISA | Mus musculus | 1 | ALA5131564 | cell-based format | Scientific Literature | |
15. | ALA5136588 | F | Inhibition of MSU-stimulated TNFalpha production in C57BL/6J mouse BMDM cells at 1 uM measured after 24 hrs by ELISA | Mus musculus | 1 | ALA5131564 | cell-based format | Scientific Literature | |
16. | ALA5136589 | F | Inhibition of staurosporine-stimulated TNFalpha production in C57BL/6J mouse BMDM cells at 1 uM measured after 24 hrs by ELISA | Mus musculus | 1 | ALA5131564 | cell-based format | Scientific Literature | |
17. | ALA5136590 | F | Inhibition of Smac-mimetic-stimulated TNFalpha production in C57BL/6J mouse BMDM cells at 1 uM measured after 24 hrs by ELISA | Mus musculus | 1 | ALA5131564 | cell-based format | Scientific Literature | |
18. | ALA5136591 | F | Inhibition of poly flagellin-stimulated TNFalpha production in C57BL/6J mouse BMDM cells at 1 uM measured after 24 hrs by ELISA | Mus musculus | 1 | ALA5131564 | cell-based format | Scientific Literature | |
19. | ALA5136592 | F | Inhibition of MDP-stimulated IL-6 production in C57BL/6J mouse BMDM cells at 1 uM measured after 24 hrs by ELISA | Mus musculus | 1 | ALA5131564 | cell-based format | Scientific Literature | |
20. | ALA5136593 | F | Inhibition of LPS-stimulated IL-6 production in C57BL/6J mouse BMDM cells at 1 uM measured after 24 hrs by ELISA | Mus musculus | 1 | ALA5131564 | cell-based format | Scientific Literature |