| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5138978 | B | Displacement of Alexa Fluor labelled Tracer-314 from human N-terminal GST-tagged mTOR incubated for 1 hr by TR-FRET assay | Homo sapiens | 23 | single protein format | Scientific Literature | ||
| 2. | ALA5138979 | B | Inhibition of PI3Kalpha in rat Rat1 cells assessed as reduction in phosphorylation of AKT at Ser473 residue incubated for 1 hr by cellular assay | Rattus norvegicus | 37 | cell-based format | Scientific Literature | ||
| 3. | ALA5138980 | B | Inhibition of PI3Kbeta in rat Rat1 cells assessed as reduction in phosphorylation of AKT at Ser473 residue incubated for 1 hr by cellular assay | Rattus norvegicus | 37 | cell-based format | Scientific Literature | ||
| 4. | ALA5138981 | B | Inhibition of PI3Kdelta in rat Rat1 cells assessed as reduction in phosphorylation of AKT at Ser473 residue incubated for 1 hr by cellular assay | Rattus norvegicus | 37 | cell-based format | Scientific Literature | ||
| 5. | ALA5138988 | A | Brain to blood ratio in OF1 mouse at 1 mg/kg, iv measured at 5 mins post dose by LC-MS/MS analysis | Mus musculus | 11 | organism-based format | Scientific Literature | ||
| 6. | ALA5138989 | A | Brain to blood ratio in OF1 mouse at 1 mg/kg, iv measured at 1 hr post dose by LC-MS/MS analysis | Mus musculus | 11 | organism-based format | Scientific Literature | ||
| 7. | ALA5138990 | A | Drug concentration in OF1 mouse blood at 1 mg/kg, iv measured at 5 mins post dose by LC-MS/MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 8. | ALA5138991 | A | Drug concentration in OF1 mouse blood at 1 mg/kg, iv measured at 1 hr post dose by LC-MS/MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 9. | ALA5138992 | A | Drug concentration in OF1 mouse brain at 1 mg/kg, iv measured at 5 mins post dose by LC-MS/MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 10. | ALA5138993 | A | Drug concentration in OF1 mouse brain at 1 mg/kg, iv measured at 1 hr post dose by LC-MS/MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 11. | ALA5138994 | A | Stability in mouse liver microsomes assessed as hepatic extraction preincubated for 3 mins followed by NADPH addition and measured after 60 mins | Mus musculus | 2 | microsome format | Scientific Literature | ||
| 12. | ALA5138995 | A | Stability in rat liver microsomes assessed as hepatic extraction preincubated for 3 mins followed by NADPH addition and measured after 60 mins | Rattus norvegicus | 3 | microsome format | Scientific Literature | ||
| 13. | ALA5138996 | A | Stability in human liver microsomes assessed as hepatic extraction preincubated for 3 mins followed by NADPH addition and measured after 60 mins | Homo sapiens | 3 | microsome format | Scientific Literature | ||
| 14. | ALA5138997 | A | Clearance in Sprague-Dawley rat at 3 mg/kg, po or iv measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 15. | ALA5138998 | A | Volume of distribution at steady state in Sprague-Dawley rat at 3 mg/kg, po or iv measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 16. | ALA5138999 | A | Half life in Sprague-Dawley rat at 3 mg/kg, po or iv measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 17. | ALA5139000 | A | AUC in Sprague-Dawley rat at 1 mg/kg, iv measured for 0.083 to 48 hrs by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 18. | ALA5139001 | A | Oral bioavailability in Sprague-Dawley rat at 3 mg/kg measured for 0.25 to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature |
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