# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5158334 | B | Inhibition of full length human recombinant HDAC6 in human MV4-11 cells assessed as acetylation of histone H3 at 5 uM by Western blot analysis | Homo sapiens | 1 | ALA5154721 | cell-based format | Scientific Literature | |
2. | ALA5158335 | B | Inhibition of full length human recombinant HDAC6 in human HD-MB03 cells assessed as increase in acetylation of alpha tubulin at 53 nM for 6 hrs by western blotting anlaysis | Homo sapiens | 1 | ALA5154721 | cell-based format | Scientific Literature | |
3. | ALA5158337 | B | Inhibition of full length human recombinant HDAC3 expressed in Sf9 baculovirus system using FAM-labeled acetylated peptide as substrate by measuring fluorescence intensity by EMSA method | Homo sapiens | 16 | ALA5154721 | cell-based format | Scientific Literature | |
4. | ALA5158338 | B | Inhibition of full length human recombinant HDAC6 expressed in Sf9 baculovirus system using FAM-labeled acetylated peptide as substrate by measuring fluorescence intensity by EMSA method | Homo sapiens | 16 | ALA5154721 | cell-based format | Scientific Literature | |
5. | ALA5158339 | B | Inhibition of full length human recombinant HDAC8 expressed in Sf9 baculovirus system using FAM-labeled acetylated peptide as substrate by measuring fluorescence intensity by EMSA method | Homo sapiens | 16 | ALA5154721 | cell-based format | Scientific Literature | |
6. | ALA5158340 | B | Inhibition of full length human recombinant HDAC11 expressed in Sf9 baculovirus system using FAM-labeled acetylated peptide as substrate by measuring fluorescence intensity by EMSA method | Homo sapiens | 16 | ALA5154721 | cell-based format | Scientific Literature | |
7. | ALA5158341 | B | Selectivity ratio of IC50 for full length human recombinant HDAC8 to IC50 for full length human recombinant HDAC6 | Homo sapiens | 16 | ALA5154721 | assay format | Scientific Literature | |
8. | ALA5158342 | F | Cytotoxicity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs measured by spectrophotometer analysis | Homo sapiens | 16 | ALA5154721 | cell-based format | Scientific Literature | |
9. | ALA5158343 | F | Cytotoxicity against human MM1.S cells assessed as inhibition of cell growth incubated for 72 hrs measured by spectrophotometer analysis | Homo sapiens | 16 | ALA5154721 | cell-based format | Scientific Literature | |
10. | ALA5158344 | T | Cytotoxicity against human MRC9 cells assessed as inhibition of cell growth incubated for 72 hrs measured by spectrophotometer analysis | Homo sapiens | 16 | ALA5154721 | cell-based format | Scientific Literature | |
11. | ALA5158345 | P | Lipophilicity, logP of the compound | 2 | ALA5154721 | small-molecule physicochemical format | Scientific Literature | ||
12. | ALA5158346 | P | Dissociation constant, pKa of compound | 1 | ALA5154721 | small-molecule physicochemical format | Scientific Literature | ||
13. | ALA5158347 | B | Binding affinity to full length human recombinant HDAC6 expressed in Sf9 baculovirus system assessed as residence time (1/koff) | Homo sapiens | 1 | ALA5154721 | cell-based format | Scientific Literature | |
14. | ALA5158348 | B | Binding affinity to full length human recombinant HDAC6 expressed in Sf9 baculovirus system assessed as inhibition constant | Homo sapiens | 2 | ALA5154721 | cell-based format | Scientific Literature | |
15. | ALA5158349 | B | Inhibition of full length human recombinant HDAC1 expressed in Sf9 baculovirus system using FAM-labeled acetylated peptide as substrate by measuring fluorescence intensity by EMSA method | Homo sapiens | 2 | ALA5154721 | cell-based format | Scientific Literature | |
16. | ALA5158350 | B | Inhibition of full length human recombinant HDAC2 expressed in Sf9 baculovirus system using FAM-labeled acetylated peptide as substrate by measuring fluorescence intensity by EMSA method | Homo sapiens | 3 | ALA5154721 | cell-based format | Scientific Literature | |
17. | ALA5158351 | B | Inhibition of full length human recombinant HDAC4 expressed in Sf9 baculovirus system using FAM-labeled acetylated peptide as substrate by measuring fluorescence intensity by EMSA method | Homo sapiens | 3 | ALA5154721 | cell-based format | Scientific Literature | |
18. | ALA5158352 | B | Inhibition of full length human recombinant HDAC5 expressed in Sf9 baculovirus system using FAM-labeled acetylated peptide as substrate by measuring fluorescence intensity by EMSA method | Homo sapiens | 2 | ALA5154721 | cell-based format | Scientific Literature | |
19. | ALA5158353 | B | Inhibition of full length human recombinant HDAC7 expressed in Sf9 baculovirus system using FAM-labeled acetylated peptide as substrate by measuring fluorescence intensity by EMSA method | Homo sapiens | 2 | ALA5154721 | cell-based format | Scientific Literature | |
20. | ALA5158354 | B | Inhibition of full length human recombinant HDAC9 expressed in Sf9 baculovirus system using FAM-labeled acetylated peptide as substrate by measuring fluorescence intensity by EMSA method | Homo sapiens | 2 | ALA5154721 | cell-based format | Scientific Literature |