# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5158480 | F | Antiviral activity against ZIKV infected in African Green monkey Vero cells assessed as reduction in viral replication | Zika virus | 2 | ALA5154725 | organism-based format | Scientific Literature | |
2. | ALA5158481 | B | Inhibition of 6-His tagged-G4SG4 fused ZIKV NS2B (49 to 95 residues) R95A mutant-NS3 (1 to 170 residue) R29G mutant expressed in Escherichia coli BL21 (DE3) using Bz-Nle-K-RR-AMC substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence assay | Zika virus | 97 | ALA5154725 | assay format | Scientific Literature | |
3. | ALA5158482 | B | Binding affinity to 6-His tagged-G4SG4 fused ZIKV NS2B (49 to 95 residues) R95A mutant-NS3 (1 to 170 residue) R29G mutant expressed in Escherichia coli BL21 (DE3) by surface plasmon resonance assay | Zika virus | 2 | ALA5154725 | assay format | Scientific Literature | |
4. | ALA5158483 | A | Stability of compound assessed 6-His tagged-G4SG4 fused ZIKV NS2B (49 to 95 residues) R95A mutant-NS3 (1 to 170 residue) R29G mutant expressed in Escherichia coli BL21 (DE3) based degradation by LC-HRMS analysis | Zika virus | 2 | ALA5154725 | assay format | Scientific Literature | |
5. | ALA5158484 | B | Inhibition of 6-His tagged-G4SG4 fused ZIKV NS2B (49 to 95 residues) R95A mutant-NS3 (1 to 170 residue) R29G mutant expressed in Escherichia coli BL21 (DE3) assessed as covalent adduct formation using Bz-Nle-K-RR-AMC substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by LC-HRMS analysis | Zika virus | 2 | ALA5154725 | assay format | Scientific Literature | |
6. | ALA5158485 | B | Inhibition of 6-His tagged-G4SG4 fused DENV2 NS2B (1394 to 1440 residues) -NS3 (1476 to 1660 residue) expressed in Escherichia coli BL21 (DE3) using Bz-Nle-K-RR-AMC substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence assay | Dengue virus | 1 | ALA5154725 | assay format | Scientific Literature | |
7. | ALA5158486 | B | Inhibition of 6-His tagged-G4SG4 fused WNV NS2B (1423 to 1470 residues) -NS3 (1506 to 1689 residue) using pERTKR-AMC substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence assay | West Nile virus | 1 | ALA5154725 | assay format | Scientific Literature | |
8. | ALA5158487 | B | Inhibition of human serine protease up to 10 uM | Homo sapiens | 1 | ALA5154725 | assay format | Scientific Literature | |
9. | ALA5158488 | B | Inhibition of human trypsin | Homo sapiens | 1 | ALA5154725 | protein format | Scientific Literature |