# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5165189 | A | Metabolic stability of compound in rat liver microsome assessed as half life at 1 uM measured upto 45 mins by LCMS analysis | Rattus norvegicus | 2 | ALA5154875 | microsome format | Scientific Literature | |
2. | ALA5165199 | F | Anti-proliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation incubated for 5 days by Cell Titre Glo luminescent assay | Homo sapiens | 40 | ALA5154875 | cell-based format | Scientific Literature | |
3. | ALA5165200 | F | Anti-proliferative activity against human K562 cells assessed as inhibition of cell proliferation incubated for 5 days by Cell Titre Glo luminescent assay | Homo sapiens | 40 | ALA5154875 | cell-based format | Scientific Literature | |
4. | ALA5165203 | A | Clearance in CD-1 mouse at 3 mg/kg, iv measured 0.083 to 24 hrs post-treatment by LC-MS/MS analysis | Mus musculus | 6 | ALA5154875 | organism-based format | Scientific Literature | |
5. | ALA5165207 | B | Competitive binding affinity to N-terminal 6xHis-SUMO-tagged human WDR5 (22 to 334 residues) expressed in Escherichia coli BL21-Gold (DE3) cells assessed as inhibition constant using 10-mer-Thr-FAM peptide as substrate incubated for 1 hr by Lantha Screen based TR-FRET assay | Homo sapiens | 39 | ALA5154875 | cell-based format | Scientific Literature | |
6. | ALA5165208 | F | Anti-proliferative activity against human MOLM-13 cells assessed as inhibition of cell proliferation incubated for 5 days by Cell Titre Glo luminescent assay | Homo sapiens | 40 | ALA5154875 | cell-based format | Scientific Literature | |
7. | ALA5165209 | A | Metabolic stability of compound in rat liver microsome assessed as intrinsic clearance at 1 uM measured upto 45 mins by LCMS analysis | Rattus norvegicus | 2 | ALA5154875 | microsome format | Scientific Literature | |
8. | ALA5165210 | F | Selectivity ratio of GI50 for human K562 cells to GI50 for human MV4-11 cells | 40 | ALA5154875 | cell-based format | Scientific Literature | ||
9. | ALA5165211 | A | AUC (0 to infinity) in CD-1 mouse at 3 mg/kg, iv measured 0.083 to 24 hrs post-treatment by LC-MS/MS analysis | Mus musculus | 6 | ALA5154875 | organism-based format | Scientific Literature | |
10. | ALA5165212 | A | Volume of distribution at steady state in CD-1 mouse at 3 mg/kg, iv measured 0.083 to 24 hrs post-treatment by LC-MS/MS analysis | Mus musculus | 6 | ALA5154875 | organism-based format | Scientific Literature | |
11. | ALA5165213 | A | Cmax in CD-1 mouse at 10 mg/kg, po measured 0.083 to 24 hrs post-treatment by LC-MS/MS analysis | Mus musculus | 5 | ALA5154875 | organism-based format | Scientific Literature | |
12. | ALA5165214 | A | AUC (0 to infinity) in CD-1 mouse at 10 mg/kg, po measured 0.083 to 24 hrs post-treatment by LC-MS/MS analysis | Mus musculus | 5 | ALA5154875 | organism-based format | Scientific Literature | |
13. | ALA5165215 | A | Half life in CD-1 mouse at 10 mg/kg, po measured 0.083 to 24 hrs post-treatment by LC-MS/MS analysis | Mus musculus | 5 | ALA5154875 | organism-based format | Scientific Literature | |
14. | ALA5165216 | A | Oral bioavailability in CD-1 mouse at 10 mg/kg measured 0.083 to 24 hrs post-treatment by LC-MS/MS analysis | Mus musculus | 5 | ALA5154875 | organism-based format | Scientific Literature | |
15. | ALA5165217 | P | Kinetic solubility of compound in PBS at pH 7.4 at 100 uM incubated for 1 hr by UV-visible spectroscopy analysis | 7 | ALA5154875 | small-molecule physicochemical format | Scientific Literature |