| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5166602 | B | Binding affinity to N-terminal 6-His tagged human LRH-1 LBD (299 to 541 residues) expressed in Escherichia coli BL21-(DE3) assessed as inhibition constant using 6N-FAM as substrate by fluorescence polarization competition assay | Homo sapiens | 3 | ALA5154902 | assay format | Scientific Literature | |
| 2. | ALA5166603 | B | Agonist activity at LRH-1 (unknown origin) transfected in human HeLa cells measured after 24 hrs by Dual Glo luciferase reporter gene assay | Homo sapiens | 3 | ALA5154902 | cell-based format | Scientific Literature | |
| 3. | ALA5166604 | B | Agonist activity at LRH-1 (unknown origin) transfected in human HeLa cells assessed as fold activation incubated for 24 hrs by DualGlo luciferase reporter gene assay | Homo sapiens | 3 | ALA5154902 | cell-based format | Scientific Literature | |
| 4. | ALA5166605 | B | Binding affinity to N-terminal 6-His tagged human LRH-1 LBD (299 to 541 residues) expressed in Escherichia coli BL21-(DE3) assessed as thermal stability by measuring melting temperature incubated overnight by fluorescence based assay | Homo sapiens | 3 | ALA5154902 | assay format | Scientific Literature | |
| 5. | ALA5166606 | B | Agonist activity at LRH-1 in human HepG2 cells assessed as upregulation of Shp mRNA expression at 10 uM measured after 24 hrs by RT-qPCR analysis | Homo sapiens | 1 | ALA5154902 | cell-based format | Scientific Literature | |
| 6. | ALA5166608 | B | Agonist activity at LRH-1 in human HepG2 cells assessed as upregulation of Cyp7a1 mRNA expression at 10 uM incubated for 24 hrs by RT-qPCR analysis | Homo sapiens | 2 | ALA5154902 | cell-based format | Scientific Literature | |
| 7. | ALA5166636 | B | Agonist activity at LRH-1 in human HepG2 cells assessed as upregulation of lipid metabolic process regulation gene at 10 uM incubated for 24 hrs by RT-qPCR based RNA-seq analysis | Homo sapiens | 1 | ALA5154902 | cell-based format | Scientific Literature | |
| 8. | ALA5166637 | B | Agonist activity at LRH-1 in human HepG2 cells assessed as upregulation of primary metabolic process regulation gene at 10 uM incubated for 24 hrs by RT-qPCR based RNA-seq analysis | Homo sapiens | 1 | ALA5154902 | cell-based format | Scientific Literature | |
| 9. | ALA5166638 | B | Agonist activity at LRH-1 in human HepG2 cells assessed as upregulation of cholestrol metabolic process gene at 10 uM incubated for 24 hrs by RT-qPCR based RNA-seq analysis | Homo sapiens | 1 | ALA5154902 | cell-based format | Scientific Literature | |
| 10. | ALA5166639 | B | Agonist activity at LRH-1 in human HepG2 cells assessed as upregulation of alpha-linolenic acid metabolic process gene at 10 uM incubated for 24 hrs by RT-qPCR based RNA-seq analysis | Homo sapiens | 1 | ALA5154902 | cell-based format | Scientific Literature | |
| 11. | ALA5166640 | B | Agonist activity at LRH-1 in human HepG2 cells assessed as upregulation of fatty acid oxidation gene at 10 uM incubated for 24 hrs by RT-qPCR based RNA-seq analysis | Homo sapiens | 1 | ALA5154902 | cell-based format | Scientific Literature | |
| 12. | ALA5166641 | B | Agonist activity at LRH-1 in human HepG2 cells assessed as upregulation of fatty acid beta-oxidation gene at 10 uM incubated for 24 hrs by RT-qPCR based RNA-seq analysis | Homo sapiens | 1 | ALA5154902 | cell-based format | Scientific Literature | |
| 13. | ALA5166642 | B | Agonist activity at LRH-1 in human HepG2 cells assessed as upregulation of steroid metabolic process at 10 uM incubated for 24 hrs by RNA-seq analysis | Homo sapiens | 1 | ALA5154902 | cell-based format | Scientific Literature | |
| 14. | ALA5166643 | B | Agonist activity at LRH-1 in human HepG2 cells assessed as upregulation of fatty acid catabolic process at 10 uM incubated for 24 hrs by RNA-seq analysis | Homo sapiens | 1 | ALA5154902 | cell-based format | Scientific Literature | |
| 15. | ALA5166644 | B | Agonist activity at LRH-1 in human HepG2 cells assessed as upregulation of phospholipid metabolic process at 10 uM incubated for 24 hrs by RNA-seq analysis | Homo sapiens | 1 | ALA5154902 | cell-based format | Scientific Literature | |
| 16. | ALA5166645 | B | Agonist activity at LRH-1 in human HepG2 cells assessed as upregulation of bile acid secretion gene at 10 uM incubated for 24 hrs by RT-qPCR based RNA-seq analysis | Homo sapiens | 1 | ALA5154902 | cell-based format | Scientific Literature | |
| 17. | ALA5166646 | B | Agonist activity at LRH-1 in human HepG2 cells assessed as upregulation of lipid hydroxylation gene at 10 uM incubated for 24 hrs by RT-qPCR based RNA-seq analysis | Homo sapiens | 1 | ALA5154902 | cell-based format | Scientific Literature | |
| 18. | ALA5166647 | B | Agonist activity at LRH-1 in human HepG2 cells assessed as upregulation of cholestrol biosynthetic process gene at 10 uM incubated for 24 hrs by RT-qPCR based RNA-seq analysis | Homo sapiens | 1 | ALA5154902 | cell-based format | Scientific Literature | |
| 19. | ALA5166692 | B | Agonist activity at LRH-1 in human HepG2 cells assessed as upregulation of Acsl1 mRNA expression at 10 uM incubated for 24 hrs by RT-qPCR based RNA-seq analysis | Homo sapiens | 1 | ALA5154902 | cell-based format | Scientific Literature | |
| 20. | ALA5166693 | B | Agonist activity at LRH-1 in human HepG2 cells assessed as upregulation of Hmgcs1 mRNA expression at 10 uM incubated for 24 hrs by RT-qPCR based RNA-seq analysis | Homo sapiens | 1 | ALA5154902 | cell-based format | Scientific Literature |
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