# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5127981 | B | Inhibition of NAE (unknown origin) | Homo sapiens | 1 | ALA5126531 | single protein format | Scientific Literature | |
2. | ALA5127982 | B | Inhibition of UAE (unknown origin) | Homo sapiens | 1 | ALA5126531 | single protein format | Scientific Literature | |
3. | ALA5151019 | B | Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glutathione and ATP by HTRF assay | Homo sapiens | 34 | ALA5149982 | protein complex format | Scientific Literature | |
4. | ALA5151022 | F | Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition by sulforhodamine B assay | Homo sapiens | 15 | ALA5149982 | cell-based format | Scientific Literature | |
5. | ALA5151023 | T | Inhibition of hERG channel | Homo sapiens | 5 | ALA5149982 | assay format | Scientific Literature | |
6. | ALA5151024 | A | Half life in Sprague-Dawley rat at 1 mg/kg, iv | Rattus norvegicus | 2 | ALA5149982 | organism-based format | Scientific Literature | |
7. | ALA5151025 | A | AUClast in Sprague-Dawley rat at 1 mg/kg, iv | Rattus norvegicus | 2 | ALA5149982 | organism-based format | Scientific Literature | |
8. | ALA5151026 | A | Observed AUCinfinity in Sprague-Dawley rat at 1 mg/kg, iv | Rattus norvegicus | 2 | ALA5149982 | organism-based format | Scientific Literature | |
9. | ALA5151027 | A | Clearance in Sprague-Dawley rat at 1 mg/kg, iv | Rattus norvegicus | 2 | ALA5149982 | organism-based format | Scientific Literature | |
10. | ALA5151028 | A | Observed MRTinfinity in Sprague-Dawley rat at 1 mg/kg, iv | Rattus norvegicus | 2 | ALA5149982 | organism-based format | Scientific Literature | |
11. | ALA5151029 | A | Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv | Rattus norvegicus | 2 | ALA5149982 | organism-based format | Scientific Literature | |
12. | ALA5151032 | B | Inhibition of UAE (unknown origin) mediated neddylation assessed as decrease in UbcH10-Ub adduct formation incubated for 2 hrs in presence of L-glutathione and ATP by HTRF assay | Homo sapiens | 2 | ALA5149982 | assay format | Scientific Literature | |
13. | ALA5151033 | B | Inhibition of SAE in human HCT-116 cells mediated neddylation assessed as decrease in Ubc9-SUMO adduct formation at 10 uM incubated for 4 hrs by Western blotting analysis | Homo sapiens | 1 | ALA5149982 | cell-based format | Scientific Literature | |
14. | ALA5151034 | B | Inhibition of UAE in human HCT-116 cells mediated neddylation assessed as decrease in UbcH10-Ub adduct formation at 3.3 uM incubated for 4 hrs by Western blotting analysis | Homo sapiens | 1 | ALA5149982 | cell-based format | Scientific Literature | |
15. | ALA5151035 | B | Inhibition of NAE in human HCT-116 cells mediated neddylation assessed as accumulation of CDT1 incubated for 24 hrs by Western blotting analysis | Homo sapiens | 1 | ALA5149982 | cell-based format | Scientific Literature | |
16. | ALA5151036 | B | Inhibition of NAE in human HCT-116 cells mediated neddylation assessed as accumulation of p27 incubated for 24 hrs by Western blotting analysis | Homo sapiens | 1 | ALA5149982 | cell-based format | Scientific Literature | |
17. | ALA5151037 | B | Inhibition of NAE in human HCT-116 cells mediated neddylation assessed as accumulation of p21 incubated for 24 hrs by Western blotting analysis | Homo sapiens | 1 | ALA5149982 | cell-based format | Scientific Literature | |
18. | ALA5151038 | B | Inhibition of NAE in human HCT-116 cells mediated neddylation assessed as accumulation of IkappaBalpha (Ser32/36) incubated for 24 hrs by Western blotting analysis | Homo sapiens | 1 | ALA5149982 | cell-based format | Scientific Literature | |
19. | ALA5151039 | B | Inhibition of NAE in human HCT-116 cells mediated neddylation assessed as increase in CHK phosphorylation incubated for 24 hrs by Western blotting analysis | Homo sapiens | 1 | ALA5149982 | cell-based format | Scientific Literature | |
20. | ALA5151040 | B | Inhibition of NAE in human HCT-116 cells mediated neddylation assessed as accumulation of gamma-H2AX incubated for 24 hrs by Western blotting analysis | Homo sapiens | 1 | ALA5149982 | cell-based format | Scientific Literature |