# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5152875 | B | Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hrs by Rapidfire mass spectrometric analysis | Homo sapiens | 13 | ALA5150036 | single protein format | Scientific Literature | |
2. | ALA5152876 | A | Efflux ratio of apparent permeability across basolateral to apical side over apical to basolateral side in MDCK-MDR1 cells at 1 uM measured after 1 hrs by LC-MS/MS analysis | Canis lupus familiaris | 13 | ALA5150036 | cell-based format | Scientific Literature | |
3. | ALA5152877 | P | 1-Octanol/aqueous buffer partition coefficient, logD of the compound at pH 7.4 by chromatographic method | 13 | ALA5150036 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA5152878 | P | Kinetic solubility of the compound in pH 6.8 JP2 fluid by precipitation method | 13 | ALA5150036 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA5152879 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance at 1 uM in the presence of NADPH regenerating system by LC/MS/MS analysis | Homo sapiens | 13 | ALA5150036 | microsome format | Scientific Literature | |
6. | ALA5152880 | A | Metabolic stability in mouse liver microsomes assessed as intrinsic clearance at 1 uM in the presence of NADPH regenerating system by LC/MS/MS analysis | Mus musculus | 13 | ALA5150036 | microsome format | Scientific Literature | |
7. | ALA5152881 | B | Inhibition of mouse GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hrs by Rapidfire mass spectrometric analysis | Mus musculus | 3 | ALA5150036 | single protein format | Scientific Literature | |
8. | ALA5152882 | A | Unbound fraction in ICR mouse plasma at 1 umol/L measured at 16 to 20 hrs by LC-MS/MS analysis | Mus musculus | 3 | ALA5150036 | cell-free format | Scientific Literature | |
9. | ALA5152883 | A | Unbound fraction in ICR mouse brain at 1 umol/L measured at 16 to 20 hrs by LC-MS/MS analysis | Mus musculus | 3 | ALA5150036 | tissue-based format | Scientific Literature | |
10. | ALA5152884 | A | Drug concentration in ICR mouse plasma at 10 mg/kg, po measured after 60 mins by LC-MS/MS analysis | Mus musculus | 3 | ALA5150036 | organism-based format | Scientific Literature | |
11. | ALA5152885 | A | Drug concentration in ICR mouse brain at 10 mg/kg, po measured after 60 mins by LC-MS/MS analysis | Mus musculus | 3 | ALA5150036 | organism-based format | Scientific Literature | |
12. | ALA5152886 | A | Unbound drug concentration in ICR mouse plasma at 10 mg/kg, po measured after 60 mins by LC-MS/MS analysis | Mus musculus | 3 | ALA5150036 | organism-based format | Scientific Literature | |
13. | ALA5152887 | A | Unbound drug concentration in ICR mouse brain at 10 mg/kg, po measured after 60 mins by LC-MS/MS analysis | Mus musculus | 3 | ALA5150036 | organism-based format | Scientific Literature | |
14. | ALA5152888 | A | Unbound brain-to-plasma concentration ratio in ICR mouse at 10 mg/kg, po measured after 60 mins by LC-MS/MS analysis | Mus musculus | 3 | ALA5150036 | organism-based format | Scientific Literature | |
15. | ALA5152889 | A | Ratio of unbound drug concentration in ICR mouse brain to IC50 for inhibition of mouse GCS using C8-ceramide and UDP-glucose as substrate | 3 | ALA5150036 | assay format | Scientific Literature | ||
16. | ALA5152890 | A | Ratio of unbound drug concentration in C57BL/6J mouse brain to IC50 for inhibition of mouse GCS using C8-ceramide and UDP-glucose as substrate | 2 | ALA5150036 | assay format | Scientific Literature | ||
17. | ALA5152891 | F | Invivo inhibition of GCS in C57BL/6J mouse assessed as decrease in glucosylceramide level in cortex at 10 mg/kg, po measured after 6 hrs by quadrupole mass spectrometry coupled UFLC analysis | Mus musculus | 1 | ALA5150036 | organism-based format | Scientific Literature |