# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5126113 | Binding | Protac activity at CRBN/CDK12 in human MDA-MB-231 cells assessed as induction of CDK12 degradation incubated for 15 hrs by immunoblotting analysis | Homo sapiens | 8 | ALA5120962 | cell-based format | Scientific Literature | |
2. | ALA5126116 | Binding | Protac activity at CRBN/CDK12 in human MDA-MB-231 cells assessed as induction of CDK12 degradation at 1 uM incubated for 15 hrs by immunoblotting analysis relative to control | Homo sapiens | 27 | ALA5120962 | cell-based format | Scientific Literature | |
3. | ALA5126117 | Binding | Protac activity at CRBN/CDK13 in human MDA-MB-231 cells assessed as induction of CDK13 degradation at 1 uM incubated for 15 hrs by immunoblotting analysis relative to control | Homo sapiens | 27 | ALA5120962 | cell-based format | Scientific Literature | |
4. | ALA5126118 | Binding | Protac activity at CRBN/CDK13 in human MDA-MB-231 cells assessed as induction of CDK13 degradation incubated for 15 hrs by immunoblotting analysis | Homo sapiens | 8 | ALA5120962 | cell-based format | Scientific Literature | |
5. | ALA5126119 | Binding | Protac activity at CRBN/CDK12 in human MFM-223 cells assessed as induction of degradation by Western blotting analysis | Homo sapiens | 1 | ALA5120962 | cell-based format | Scientific Literature | |
6. | ALA5126120 | Binding | Protac activity at CRBN/CDK13 in human MFM-223 cells assessed as induction of degradation by Western blotting analysis | Homo sapiens | 1 | ALA5120962 | cell-based format | Scientific Literature | |
7. | ALA5126121 | Binding | Protac activity at CRBN/CDK12 in human MDA-MB-231 cells assessed as induction of degradation by Western blotting analysis | Homo sapiens | 1 | ALA5120962 | cell-based format | Scientific Literature | |
8. | ALA5126122 | Binding | Protac activity at CRBN/CDK13 in human MDA-MB-231 cells assessed as induction of degradation by Western blotting analysis | Homo sapiens | 1 | ALA5120962 | cell-based format | Scientific Literature | |
9. | ALA5126123 | Binding | Protac activity at CRBN/CDK12 in human MFM-223 cells assessed as induction of degradation at 500 nM incubated upto 24 hrs by Western blotting analysis | Homo sapiens | 1 | ALA5120962 | cell-based format | Scientific Literature | |
10. | ALA5126124 | Binding | Protac activity at CRBN/CDK12 in human MDA-MB-231 cells assessed as induction of degradation at 500 nM incubated upto 24 hrs by Western blotting analysis | Homo sapiens | 1 | ALA5120962 | cell-based format | Scientific Literature | |
11. | ALA5126125 | Binding | Protac activity at CRBN/CDK13 in human MFM-223 cells assessed as induction of degradation at 500 nM measured after 4 hrs by Western blotting analysis | Homo sapiens | 1 | ALA5120962 | cell-based format | Scientific Literature | |
12. | ALA5126126 | Binding | Protac activity at CRBN/CDK13 in human MDA-MB-231 cells assessed as induction of degradation at 500 nM measured after 4 hrs by Western blotting analysis | Homo sapiens | 1 | ALA5120962 | cell-based format | Scientific Literature | |
13. | ALA5126127 | Binding | Protac activity at CRBN/CDK12 in human MDA-MB-231 cells assessed as degradation of CDK12 at 500 nM measured after 6 hrs in presence of carfilzomib by Western blot analysis | Homo sapiens | 1 | ALA5120962 | cell-based format | Scientific Literature | |
14. | ALA5126128 | Binding | Protac activity at CRBN/CDK13 in human MDA-MB-231 cells assessed as degradation of CDK13 at 500 nM measured after 6 hrs in presence of carfilzomib by Western blot analysis | Homo sapiens | 1 | ALA5120962 | cell-based format | Scientific Literature | |
15. | ALA5126129 | Binding | Protac activity at CRBN/CDK12 in human MDA-MB-231 cells assessed as degradation of CDK12 at 500 nM measured after 6 hrs in presence of bafilomycin by Western blot analysis | Homo sapiens | 1 | ALA5120962 | cell-based format | Scientific Literature | |
16. | ALA5126130 | Binding | Protac activity at CRBN/CDK13 in human MDA-MB-231 cells assessed as degradation of CDK13 at 500 nM measured after 6 hrs in presence of bafilomycin by Western blot analysis | Homo sapiens | 1 | ALA5120962 | cell-based format | Scientific Literature | |
17. | ALA5126131 | Binding | Protac activity at CRBN/CDK12 in human MDA-MB-231 cells assessed as inhibition of degradation of CDK12 at 500 nM measured after 6 hrs in presence of thalidomide | Homo sapiens | 1 | ALA5120962 | cell-based format | Scientific Literature | |
18. | ALA5126132 | Binding | Protac activity at CRBN/CDK13 in human MDA-MB-231 cells assessed as inhibition of degradation of CDK13 at 500 nM measured after 6 hrs presence of thalidomide | Homo sapiens | 1 | ALA5120962 | cell-based format | Scientific Literature | |
19. | ALA5126133 | Functional | Downregulation of CDK12 in human MDA-MB-231 cells at 100 to 500 nM by Western blot analysis | Homo sapiens | 1 | ALA5120962 | cell-based format | Scientific Literature | |
20. | ALA5126134 | Functional | Downregulation of CDK13 in human MDA-MB-231 cells at 100 to 500 nM by Western blot analysis | Homo sapiens | 1 | ALA5120962 | cell-based format | Scientific Literature |