# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5099704 | A | Plasma clearance in Wistar Han rat | Rattus norvegicus | 1 | ALA5096227 | assay format | Scientific Literature | |
2. | ALA5099705 | B | Inhibition of human DGAT2 expressed in Sf9 insect cell membrane using [1-14C]decanoyl-CoA and 1,2-didecanoyl-sn-glycerol as substrates assessed as incorporation of [1-14C]decanoyl into triacylglycerol preincubated for 120 mins followed by substrate addition and measured after 40 mins by scintillation counting method | Homo sapiens | 12 | ALA5096227 | cell membrane format | Scientific Literature | |
3. | ALA5099706 | P | Lipophilicity, logD of compound at pH 7.4 by shake flask method | 12 | ALA5096227 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA5099707 | A | Apparent intrinsic clearance in cryopreserved human hepatocytes measured per million cells at 1 uM incubated for 4 hrs by LC-MS/MS analysis | Homo sapiens | 10 | ALA5096227 | cell-based format | Scientific Literature | |
5. | ALA5099708 | A | Apparent intrinsic clearance in human liver microsomes in presence of NADPH | Homo sapiens | 3 | ALA5096227 | microsome format | Scientific Literature | |
6. | ALA5099709 | B | Inhibition of mouse MGAT1 using [1-14C]decanoyl-CoA and 2-oleoylglycerol as substrates assessed as incorporation of [1-14C]decanoyl into diacylglycerol preincubated for 30 mins followed by substrate addition and measured after 30 to 90 mins by scintillation counting method | Mus musculus | 2 | ALA5096227 | single protein format | Scientific Literature | |
7. | ALA5099710 | B | Inhibition of human MGAT2 using [1-14C]decanoyl-CoA and 1-decanoyl-rac-glycerol as substrates assessed as incorporation of [1-14C]decanoyl into diacylglycerol preincubated for 30 mins followed by substrate addition and measured after 30 to 90 mins by scintillation counting method | Homo sapiens | 2 | ALA5096227 | single protein format | Scientific Literature | |
8. | ALA5099711 | B | Inhibition of human MGAT3 using [1-14C]decanoyl-CoA and 1,2-didecanoyl-sn-glycerol as substrates assessed as incorporation of [1-14C]decanoyl into diacylglycerol preincubated for 30 mins followed by substrate addition and measured after 30 to 90 mins by scintillation counting method | Homo sapiens | 2 | ALA5096227 | single protein format | Scientific Literature | |
9. | ALA5099712 | B | Inhibition of human DGAT1 using [1-14C]decanoyl-CoA and 1,2-didecanoyl-sn-glycerol as substrates assessed as incorporation of [1-14C]decanoyl into diacylglycerol preincubated for 30 mins followed by substrate addition and measured after 30 to 90 mins by scintillation counting method | Homo sapiens | 2 | ALA5096227 | single protein format | Scientific Literature | |
10. | ALA5099713 | A | Apparent permeability in MDCK-II cells | Canis lupus familiaris | 11 | ALA5096227 | cell-based format | Scientific Literature | |
11. | ALA5099714 | A | Reversible inhibition of CYP1A2 in pooled human liver microsomes using acetaminophen as substrate incubated for 20 mins in presence of NADPH by HPLC-MS/MS analysis | Homo sapiens | 2 | ALA5096227 | microsome format | Scientific Literature | |
12. | ALA5099715 | A | Reversible inhibition of CYP3A4/5 in pooled human liver microsomes | Homo sapiens | 2 | ALA5096227 | microsome format | Scientific Literature | |
13. | ALA5099716 | A | Reversible inhibition of CYP2B6 in pooled human liver microsomes | Homo sapiens | 2 | ALA5096227 | microsome format | Scientific Literature | |
14. | ALA5099717 | A | Reversible inhibition of CYP2C8 in pooled human liver microsomes using desethylamodiaquine as substrate incubated for 10 mins in presence of NADPH by HPLC-MS/MS analysis | Homo sapiens | 2 | ALA5096227 | microsome format | Scientific Literature | |
15. | ALA5099718 | A | Reversible inhibition of CYP2C9 in pooled human liver microsomes using 4-Hydroxydiclofenac as substrate incubated for 10 mins in presence of NADPH by HPLC-MS/MS analysis | Homo sapiens | 2 | ALA5096227 | microsome format | Scientific Literature | |
16. | ALA5099719 | A | Reversible inhibition of CYP2C19 in pooled human liver microsomes using 4-Hydroxymephenytoin as substrate incubated for 20 mins in presence of NADPH by HPLC-MS/MS analysis | Homo sapiens | 2 | ALA5096227 | microsome format | Scientific Literature | |
17. | ALA5099720 | A | Reversible inhibition of CYP2D6 in pooled human liver microsomes using dextrorphan as substrate incubated for 14 mins in presence of NADPH by HPLC-MS/MS analysis | Homo sapiens | 2 | ALA5096227 | microsome format | Scientific Literature | |
18. | ALA5099721 | A | Volume of distribution at steady state in Wistar Han rat | Rattus norvegicus | 1 | ALA5096227 | assay format | Scientific Literature | |
19. | ALA5099722 | A | Half life in Wistar Han rat | Rattus norvegicus | 1 | ALA5096227 | assay format | Scientific Literature | |
20. | ALA5099723 | A | Oral bioavailability in Wistar Han rat at 5 mg/kg | Rattus norvegicus | 2 | ALA5096227 | organism-based format | Scientific Literature |