| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5159397 | F | Induction of DNA damage in human LoVo cells deficient in ATM at 1 uM measured after 3 days by immunofluorescence assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA5159398 | F | Induction of apoptosis in human HT-29 cells assessed as viable cells at 1 uM measured after 48 hrs in presence of AZD1390 by Annexin V-FITC/Propidium iodide staining based flow cytometry analysis (Rvb = 95.33%) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA5159399 | F | Induction of apoptosis in human HT-29 cells assessed as early apoptotic cells at 1 uM measured after 48 hrs in presence of AZD1390 by Annexin V-FITC/Propidium iodide staining based flow cytometry analysis (Rvb = 3.81%) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA5159400 | F | Antiproliferative activity against ATM proficient human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA5159401 | F | Cytotoxicity against ATM proficient human HT-29 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA5159402 | F | Antiproliferative activity against ATM proficient human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA5159403 | F | Antiproliferative activity against ATM proficient human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA5159404 | F | Antiproliferative activity against ATM-deficient human OVCAR-3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA5159405 | F | Antiproliferative activity against ATM-deficient human LoVo cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA5159406 | F | Antiproliferative activity against ATM-deficient human Granta-519 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA5159407 | F | Antiproliferative activity against ATM-deficient human NCI-H23 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA5159408 | F | In vivo inhibition of ATR in human LoVo cells xenografted in NOD/SCID mouse assessed as inhibition of ATR phosphorylation at 50 to 100 mg/kg, po administered twice a day for 30 days by Western blot analysis | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA5159409 | F | Antiproliferative activity against ATM-deficient human SW-620 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA5159410 | F | Antiproliferative activity against ATM proficient human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA5159411 | B | Inhibition of human recombinant full length ATR using GST-cMyc-p53 as substrate incubated for 40 mins in presence of ATP by HTRF assay | Homo sapiens | 44 | single protein format | Scientific Literature | ||
| 16. | ALA5159412 | B | Inhibition of ATR signalling in ATM-deficient human LoVo cells assessed as inhibition of ATR phosphorylation incubated for 1 hr followed by hydroxyurea addition measured after 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA5159413 | B | Inhibition of ATR signalling in ATM-deficient human LoVo cells assessed as inhibition of Chk1 phosphorylation incubated for 1 hr followed by hydroxyurea addition measured after 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA5159414 | F | Inhibition of colony formation in human LoVo cells assessed as inhibition of cell proliferation incubated for 24 hrs followed by culture medium replenishment with drug-free medium for every 72 hrs and measured after 14 days by crystal violet staining method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA5159415 | F | Antimigratory activity in human LoVo cells assessed as suppression of cell migration measured up to 48 hrs by wound healing assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA5159416 | F | Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability incubated for 72 hrs in presence of AZD1390 by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature |
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